Current Issue cover

Preservative Efficacy Testing of Aqueous Cosmetics and Drugs without Counting Colonies

Contact Author D.S. Orth and K.S. Delgadillo Eck, Neutrogena Corp.
Fill out my online form.

Preservative efficacy testing or "challenge testing" is performed on aqueous cosmetic and drug products to determine the minimum effective concentration of antimicrobial preservatives required for adequate preservation. Products are satisfactorily preserved if they meet appropriate acceptance criteria. Methods of preservative efficacy testing include: compendial methods, such as the United States Pharmacopoeia (USP) and the European PHarmacopoeia (EP) methods; trade association methods, such as the Cosmetic, Toiletry & Fragrance Association (CTFA) method; and rapid procedures, such as the linear regression method.1-4

Related Content

  • Good As Gold: Validating Alternative SPF Test Methods
    4/3/2020, Uli Osterwalder, Sun Protection Facilitator (SPF) GmbH, Basel, Switzerland; Steffen Uhlig, Ph.D., and Bertrand Colson, QuoData Quality and Statistics GmbH, Berlin and Dresden, Germany; Jürgen Vollhardt, Ph.D., DSM Nutritional Products Ltd., Switzerland


Next image >