Hallmarks of ageing refer to biological changes associated with ageing. They share three key characteristics:
- They occur naturally as part of the ageing process,
- Their increase leads to premature ageing, and
- Their decrease through interventions can help delay or reverse visible signs of ageing.
At a cellular level, there are 12 hallmarks of ageing (1) . These are highly interconnected and divided into 3 groups (2),(3)
- Primary causes of damage: Genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy
- Antagonists (response to damage): Mitochondrial dysfunction, nutrient sensing dysregulation, cellular senescence
- Integratives (manifestations of ageing): chronic inflammation, altered intercellular communication, stem cell exhaustion, dysbiosis
Fig 1. Hallmarks of ageing. These hallmarks provide a powerful framework for understanding skin ageing at the cellular level. They drive skin ageing by impairing cellular function, increasing oxidative stress and triggering micro-inflammation. This weakens the barrier function and reduces skin elasticity and firmness. Understanding these hallmarks allows to develop active ingredients with specific mechanism of action to better answer most of the beauty concerns.
The Power of Regenerative Science-backed Ingredients
Mintel reported that 55% of German women aged 55+ agree that active ingredients are the most important when choosing facial skincare. At Croda Beauty, we are pioneering the future of skin care with innovative solutions that go beyond aesthetics and specifically target each hallmark of ageing. By integrating targeted active ingredients, we help brands create effective, future-facing products that support long-term skin resilience and vitality.
Key innovations include clinically proven ingredients that maintain optimal cellular function and regenerative capacity.
| Innovation area | What it does | Example of ingredients |
| Cell biohacking actives | Optimise cellular processes, improve skin resilience, and slow visible signs of ageing | Luceane™ – enhances mitochondrial function to counteract pollution-induced hypoxiageing™ Chromocare™ – supports cell autophagy for more radiant, brighter skin Matrixyl Morphomics™ – stimulates the expression of youthful genes, referred to as longevigenes™ to smooth vertical lines that give a sad look Crystalide™ – regulates epidermis renewal epigenetic mechanisms to provide a glass skin appearance Resistem™ – Adaptogenic that induces a hormetic effect (vaccination-like) that soothes the skin and improves its resistance to external aggressions Mel[o]stem™ – senotherapeutic that modulates cellular senescence to reduce the appearance of sun-induced dark and white spots |
| Neurocosmetics | Interact with the skin nervous system to support emotional well-being | Zenakine™ – works in sync with skin circadian rhythm by stimulating the production of melatonin and happy messengers into the skin to enhance sleep quality, mood and skin resilience to physical and emotional stress |
| AI-driven personalisation | Enable tailored skin care solutions based on individual needs and real-time skin diagnostics | Moist 24™ – provides deep, long-lasting hydration to dry to very dry skin including consumers with black skin Amberstem™ – controls hyperpigmentation for consumers with olive complexions (III to V skin phototypes with golden, greenish or yellowish undertones), prone to inflammation |
The Future of Beauty
The longevity trend represents a revolution in the cosmetics industry, driven by:
- Scientific advancements in regenerative skin care
- Consumer demand for long-term skin resilience
- A proactive shift from traditional anti-ageing to preventative beauty
- The rise of hyper-personalised, AI-driven solutions
By embracing a holistic, science-driven approach, the future of beauty merges aesthetics with skin health, ensuring sustained wellness and radiance. This market evolution redefines luxury, making science-backed, wellness-focused skin care the new gold standard in beauty.
[Download our guide to the hallmarks of ageing]
References:
(1)Hallmarks of aging: An expanding universe
(2)Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction
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