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63 Results

Type: Article

Section: Testing > Safety/Stability

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Cosmetovigilance and Safety Assessment in the World of Active Ingredients

It can be deduced from today's scientific literature that countless ingredients have been developed with the intent to alter the structure and function of human skin. This raises important questions in terms of how these products should be regulated and what types of safety standards they should be held to.

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Tanning and Whitening Can Be Risky Business

Both skin tanning and whitening products, especially those not approved, can carry serious health risks. This column will review regulatory aspects of tanning products, radiation-emitting devices, skin colorants and cosmetics, drugs and supplements, and skin whiteners to make formulators aware of these risks.

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3 Skin Sensitization Tests to Meet the EU Mandate

The EU Cosmetics Regulation requires skin sensitization to be determined through non-animal methods. Here, the pathways for skin sensitization are reviewed, three non-animal tests are described in brief, and their combination with one another, followed by human assessment, are explored.

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Lab Lessons—Wise Words from the Bench with Mark Chandler

Cosmetics & Toiletries presents “Lab Lessons,” featuring interviews with veteran members of the personal care industry to share practical advice from the lessons they have learned.

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Bypassing Adverse Skin Pathways: EU Rules for Cosmetics Tox Testing

Skin sensitization is one of the critical endpoints used to assess cosmetic ingredient safety, as highlighted in the EU regulation. Considerations for non-animal skin sensitization testing are discussed here.

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9 EU Requirements for Risk Assessment

An ingredient's highest safe dose divided by its exposure equals its margin of safety; that's the gist of the EU's risk assessment . This sixth article in a series covers the specific requirements for risk determination.

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Safer Solar Protection: Going Beyond UV Defense, Part I

This two-part article is controversial. In part I, it reviews a number of concerns about the safety of traditional sunscreens. In part II, scheduled for February, the authors propose new approaches to move past these issues.

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Enhanced with Critical Thinking

Butterflies in my stomach, that’s what I’m feeling. Both excited and nervous. Why? In this issue of Cosmetics & Toiletries, we’re trying something different. Our cover story is about safer sun protection but not in a way you’re used to; it's controversial.

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10 Aspects of Cosmetics Data Mandated by the EU

Product safety: It's crucial. That's why European Regulation (EC) No. 1223/2009 requires the following 10 aspects of cosmetic product data to be provided in order to support a proper safety assessment.

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Patent Pick: Placating Intolerant Skin

Sensitive skin is irritating to the wearer, and in some cases the formulator, but Beiersdorf inventors have discovered an ingredient that placates irritated skin: alkylamidothiazoles.

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Testing the Fate (and Exposure) of Cosmetic Ingredients

Risk and exposure go hand-in-hand. So when researchers dared to publish a new method to assess the exposure and fate of cosmetic ingredients, we couldn't help but give them exposure, in this review.

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You Think Your Product's Ready for Europe?

Europe's Cosmetics Regulation requires that, prior to their market release, cosmetic products undergo a safety assessment. From this, a safety report is drawn up for each product. In this column, we show you what elements of data you’ll need to gather.

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Fast Analysis of Cosmetic Allergens Using Convergence Chromatography with Mass Spectrometry

Fragrances are complex combinations of substances that are added to many consumer products to give them a distinctive smell, impart a pleasant odor, or mask the inherent smell of some ingredients—but ultimately, to enhance the experience of the product user.

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Phthalates Study Raises More Concerns, ‘But Who Cares?’

It’s been a while since a cosmetic ingredient was slandered. To ensure we’re not letting you down, here’s a report on new study examining the negative impact of phthalates.

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'Zapping' Sensitive Skin: Capsaicin Tests Show Embelia concinna Comforts Irritation

In previous work, a flavonoid-titrated active ingredient based on Embelia concinna was shown in vitro to calm and soothe sensory neurons stimulated with capsaicin. Here, those results are confirmed in vivo using a capsaicin stinging test with human volunteers.

Nanotechnology: A Big Deal in a Small Package

Nanotechnology and nanomaterials open up an abundance of options for cosmetic formulators to develop innovative new products. Likewise, they open up an abundance of regulatory concerns. Here’s a look at the regulatory implications of nanomaterials in skin care applications.

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Gauging Cosmetic Safety in a Post-Animal Testing World

The testing of cosmetic and personal care products on animals has become widely perceived as a vile, often cruel and inhumane practice. Many countries have either banned its use or have pending legislation to do so. The dilemma this leaves is creating reliable methods to test products for safety and quality.

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Free Formaldehyde Preservative Stability in Personal Care: Part I—Water

As scrutiny of formaldehyde-donor (FD) and other preservative technologies has increased in recent years, additional assurances of the relative safety and benefits of FD technologies are required. This two-part article examines the effects of temperature and pH on free-formaldehyde levels (as detected by C-13 NMR), first in water, then in personal care formulations.

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