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144 Results

Section: Testing > Method/Process

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Methylene Blue—The Antioxidant Answer to Aging?

The antioxidant methylene blue may be the answer to slow down aging, according to new research from the University of Maryland. Scientists are already formulating products for consumer use with the chemical.

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SPF Testing: Who's Got Their 'Backs?'

"Isn’t it time for governments and industry to standardize an in vitro SPF test to replace human testing?" Karl Laden, Ph.D., of Alpa Cosmetics, asks in this brief commentary. What do you think?

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Shiseido Tech Takes Personalization to the Exposome

How can custom skin care become more customized? Shiseido believes by plotting skin conditions in real-time as a function of environmental factors. A new smart phone-driven system does just that.

Skin Toxicology—The Future May Be Orange

Here, industry expert Johann Wiechers, PhD, discusses the frequent use of percentages by toxicologists to calculate skin penetration. To relate this discussion to modern day events, Wiechers describes the skin penetration of orange paint, used by fans of the Dutch national football team.

Predicting the Percutaneous Penetration of Cosmetic Ingredients

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

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[podcast] What We Know About the Skin Microbiome

Where is the cosmetics industry in terms of understanding the skin microbiome? And what approaches could engage or support the entities therein? Larry Weiss, M.D., tells us, in this exclusive interview. Listen now.

Testing for Penetration of the Skin Barrier

The skin barrier is described, after which tests and case studies illustrate how to show if actives and other ingredients have or have not penetrated the skin barrier.

The Safety Factor in Preservative Efficacy Testing

The authors explain how preservative efficacy testing is done to determine whether a formula is adequately preserved. Product contamination problems are frequently caused by inadequate preservation.

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FDA Sets Regulatory Framework for Regenerative Biological Therapies

It's a sign of the times when technology and innovation hit a point where the U.S. Food and Drug Administration must stop and write new rules to ensure consumer safety. That time, with respect to regenerative biological therapies, is now.

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Untouched, 'Primitive' Microbiome Sets the Skin Health Benchmark

As it turns out, on skin, the more "bugs," the better; and cosmetics could be negatively affecting their diversity. New research from the UK compared microbiomes to set a "healthy skin standard," against which the effects of products can be measured, in the future.

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Measuring the Antioxidant Potential of an Acai Extract

The antioxidant potential of cosmetic materials can be evaluated by several methodologies, including a commercial kit that measures total antioxidant status, as illustrated here with a commercial extract from the fruit of the açaí, a Brazilian palm tree. Applications in antiaging products are suggested.

Measuring the Antioxidant Potential of an Acai Extract

The antioxidant potential of cosmetic materials can be evaluated by several methodologies, including a commercial kit that measures total antioxidant status, as illustrated here with a commercial extract from the fruit of the açaí, a Brazilian palm tree. Applications in antiaging products are suggested.

A Hair Dyeing Solution for the Dye-allergic Consumer

This article describes how to identify allergic contact dermatitis resulting from hair dye, and outlines prevention principles for those who wish to continue dyeing their hair despite being allergic—with clear implications for those formulating these products. The main sensitizers in hair dye are discussed, along with techniques to minimize exposure to these allergenic substances.

Wise Words From the Bench with Gavin Greenoak

After 25 years in the industry, Gavin Greenoak, managing and scientific director of the Australian Photobiology Testing Facility Pty., Ltd. (APTF), continues to strive for a better understanding of the interaction of light and the human body. Greenoak’s career began in cancer research, which has afforded him unique insight of skin biology and the effects of sun exposure.

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3 Skin Sensitization Tests to Meet the EU Mandate

The EU Cosmetics Regulation requires skin sensitization to be determined through non-animal methods. Here, the pathways for skin sensitization are reviewed, three non-animal tests are described in brief, and their combination with one another, followed by human assessment, are explored.

Biochip Takes the Next Step Toward Replacing Animal Testing

Researchers at Rensselaer, the University of California-Berkeley, and Solidus Biosciences Inc. have developed a biochip that can mimic the effects of metabolism and analyze materials for toxicity.

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Hidden Hair Damage and the Importance of Multiple Tests

It is of paramount importance for hair researchers to know the history of hair at the time of applying a treatment. The lack of such knowledge can create misleading results. Thus, a stress-strain test in both dry and wet states can provide a rapid means to check the reliability of the information collected, as is shown here.

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Testing the Fate (and Exposure) of Cosmetic Ingredients

Risk and exposure go hand-in-hand. So when researchers dared to publish a new method to assess the exposure and fate of cosmetic ingredients, we couldn't help but give them exposure, in this review.

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