A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

In past decades, the understanding of mechanisms for skin penetration has significantly improved.1 Studies have identified the stratum corneum (SC), the outermost layer of the skin, as the main barrier for penetration of pharmaceutical and cosmetic ingredients,2 and due to its unique composition—i.e., about 50% ceramides, 35% free fatty acids and 15% cholesterol—the SC differs from other biological membranes.3 To facilitate the development of transdermal delivery for the compounds of interest, estimations of skin penetration rates and comparisons of dermatological formulations have become crucial to pharmaceutical and cosmetics research.4

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