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Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Apr 4, 2013 | Olga V. Dueva-Koganov, PhD, Artyom Duev and Steven Micceri, AkzoNobel Surface Chemistry

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.

Hair Ethnicity and Ellipticity: A Preliminary Study

Apr 4, 2013 | Ali N. Syed, PhD; Tomas N. Ventura Jr.; and Maliha N. Syed, Avlon Industries Inc.

Ethnic hair care addresses diverse fiber compositions that require unique products. This comprehensive review in hair fiber dimensions among straight, wavy and curly/coily hair serves as a basis from which product developers can design products to cater to unique hair type needs. The current study examines the ellipticity of Caucasian, Brazilian, Hispanic and African-American hair.

Hair Ethnicity and Ellipticity: A Preliminary Study

Apr 4, 2013 | Ali N. Syed, PhD; Tomas N. Ventura Jr.; and Maliha N. Syed, Avlon Industries Inc.

Ethnic hair care addresses diverse fiber compositions that require unique products. This comprehensive review in hair fiber dimensions among straight, wavy and curly/coily hair serves as a basis from which product developers can design products to cater to unique hair type needs. The current study examines the ellipticity of Caucasian, Brazilian, Hispanic and African-American hair.

Adjusting Substrate/Product Interfacial Properties to Improve In vivo/In vitro SPF Correlation

Apr 3, 2013 | S. Miksa, D. Lutz and J. Ongenaed, HelioScreen Labs; D. Candau, L’Oréal Research & Innovation

This work evaluates the impact of a plasma treatment on test substrates to modify their surface energy, to more closely correlate in vitro SPF measurements with in vivo measurements—without chemically altering the test products. The authors chose the level of plasma modification to use on a substrate based on in vivo values; they explain how to choose it regarding specific formulas in a further paper.

The Effect of Skin Metabolism on the Absorption of Chemicals

Apr 3, 2013 | Alain Mavon, PhD, and Carine Jacques-Jamin, PhD, Oriflame Cosmetics AB, Skin Research Institute

Skin expresses enzymes that can metabolize endogenous molecules but little is known regarding how they impact the delivery of xenobiotics. This review of recent works shows that skin metabolism alters the dermal absorption of lipophilic compounds, which opens new areas of investigation regarding the safety and efficacy of topically applied cosmetics.

The Effect of Skin Metabolism on the Absorption of Chemicals

Apr 3, 2013 | Alain Mavon, PhD, and Carine Jacques-Jamin, PhD, Oriflame Cosmetics AB, Skin Research Institute

Skin expresses enzymes that can metabolize endogenous molecules but little is known regarding how they impact the delivery of xenobiotics. This review of recent works shows that skin metabolism alters the dermal absorption of lipophilic compounds, which opens new areas of investigation regarding the safety and efficacy of topically applied cosmetics.

A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

Mar 5, 2013 | Konstantin Tsinman, PhD, Pion Inc.; Bálint Sinkó, PhD, SinkoLAB Scientific Bt.

This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.

Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Mar 5, 2013 | Olga V. Dueva-Koganov, PhD, Artyom Duev and Steven Micceri, AkzoNobel Surface Chemistry

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.

Adjusting Substrate/Product Interfacial Properties to Improve In vivo/In vitro SPF Correlation

Mar 5, 2013 | S. Miksa, D. Lutz and J. Ongenaed, HelioScreen Labs; D. Candau, L’Oréal Research & Innovation

This work evaluates the impact of a plasma treatment on test substrates to modify their surface energy, to more closely correlate in vitro SPF measurements with in vivo measurements—without chemically altering the test products. The authors chose the level of plasma modification to use on a substrate based on in vivo values; they explain how to choose it regarding specific formulas in a further paper.

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