Silab has developed Commusys (INCI: Not Provided), a natural anti-aging active ingredient rich in biopeptides derived from the yeast Pichia stipitis, which acts on transcompartmental communication in the skin.
By regulating the molecular players involved in communication from the dermis to the epidermis, the ingredient reactivates epidermal biological functions for hydrating, smoothing and radiance-boosting effects.
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Silab's research in transcompartmental communication between the dermis and the epidermis during aging led to an in vitro modeling study where the mediators involved in dermal-epidermal communication were mapped. This highlighted the major role of the proteome, miRNA expression in extracellular vesicles (including exosomes) and the IGF-1/IGF-1R pathway. Silab demonstrated that these mediators were deregulated during aging, leading to a communication shortfall that impairs the biological functions of the epidermis.
Given this observation, the company developed Commusys, an active ingredient capable of regulating the molecular players involved in communication from the dermis to the epidermis, thereby reactivating epidermal functions. Indeed, the secretome of aged fibroblasts treated with 0.4% Commusys increases keratinocyte processes such as cell proliferation and cohesion, keratinocyte differentiation, hydration and anchoring of keratinocytes at the dermal-epidermal junction, per the company.
These results translate in vivo on a mature Caucasian panel into positive effects on epidermal renewal and thickness, assessed using optical biopsies. The skin of Caucasian and Asian volunteers is hydrated, smoothed and radiant after a twice-daily use of 1.7% Commusys, per the company.
