The efficacy and safety of cosmetic products depends on the chemical structure and toxicological profile of their ingredients, as well as the levels of these ingredients that the user will encounter. These parameters are not only linked to the ingredients in a formulation, but also to what they become on the skin. Studies have reported that skin absorption of the same ingredient in different topical formulations can differ as much as 10 to 50 times.1 Moreover, determining absorption itself is challenging due to the complexity of structures and mechanisms constituting the skin delivery pathway. Delivery depends on various parameters, including the physicochemical properties of the active ingredient, skin condition, formulation type, etc.
A Novel Explant Model for Skin Delivery Assessment
Feb 25th, 2015