3D Skin Substrate Meets Speed, Complexity and ECM-based Research Needs

Jun 15th, 2020

Rachel Grabenhofer

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Dental medicine may not be the first field you think of when it comes to developing skin test substrates but researchers from the University School of Dental Medicine in Boston have published an approach to produce 3D skin-like tissues with potential cosmetic application.

According to the article abstract, published in Tissue Engineering and Regenerative Medicine, specific factors can improve in vitro 3D skin tissues: human‐derived extracellular matrix (ECM), higher throughput tissue formats and greater cellular complexity. The present work addresses these factors.

The researchers demonstrated that human adult and neonatal fibroblasts deposit an endogenous ECM de novo to support full epithelial tissue development and differentiation. These were miniaturized into a 24‐well format to adapt for eventual higher throughput screening.

Furthermore, monocytes from peripheral blood can be incorporated into this model as macrophages to increase tissue complexity. This model could screen for inflammatory responses in human skin.

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The sensitivity of the test indicates it could be useful as a screening tool and could contribute to research on alternative skin corrosion tests.

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The CTPA and the U.K. cosmetic industry wants to promote the use of new approach methodologies (NAMs) as alternatives to animal testing for these vital safety requirements under other chemicals legislation, especially UK Reach.

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The CTPA and the U.K. cosmetic industry wants to promote the use of new approach methodologies (NAMs) as alternatives to animal testing for these vital safety requirements under other chemicals legislation, especially UK Reach.

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