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Section: Testing > Efficacy

For desirable hair styles, both stiffness and flexibility are necessary – but the two properties are generally considered incompatible.

Isomalto-oligosaccharides Naturally Balance ‘Stiffness’ with Flexibility for Hair Styling Benefits

This article describes enzymatically controlled naturally derived isomalto-oligosaccharides. It demonstrates how they balance stiffness and flexibility to maintain hair styles, as well as reduce the need for synthetic setting polymers.

After 14 days, M. cochinchinensis extract improved stinging, irritation, itch and discomfort by 67%, 100%, 91% and 100%, respectively.

Holistically Derailing the Sensitive Scalp ‘Rollercoaster’

A Maclura cochinchinensis extract was developed to provide holistic relief for sensitive scalps by derailing multiple interconnected aspects of this “rollercoaster” condition. The active’s efficacy was tested in vitro and in vivo as described here.

To provide a natural solution for sensitive skin, a hyperbranched dextrin was developed and tested for soothing and protective effects. The absence of adverse effects on the microbiome also was assessed by a third party, with promising results.

Hyperbranched Dextrin for Soothing, Microbiome-friendly Skin Care

To provide a natural solution for sensitive skin, a hyperbranched dextrin was developed and tested for soothing and protective effects. The absence of adverse effects on the microbiome also was assessed by a third party, with promising results.

Transdermal microneedle patches enable active ingredients to bypass the slow diffusional process across the stratum corneum’s barrier to reach directly into the deeper skin layers.

How Dissolving HA Microneedles Change Before/After Application

Dissolvable microneedles have gained popularity to overcome the skin barrier and deliver actives. Here, SEM was used to evaluate changes that occur to microneedles upon application. The results could provide claims and regulatory classification insights.

The present study examined the effects of commercially available jojoba esters in liquid, natural jojoba-like form in three studies measuring irritation mitigation, skin hydration and soothing properties.

Jojoba Oil Esters Ease Inflammation, Sensitivity and Water Loss from Skin and the Environment

Water scarcity has become a major concern and jojoba is known to flourish under controlled low water conditions. As such, jojoba wax esters were explored for skin care to reduce inflammation and sensitivity and to provide hydration over a 24-hr period.

Xylyx Bio Matrikynes Exhibits Clinical Anti-aging, Barrier Repair Efficacy

The ingredient is based on matrikines, whose intrinsic bioactivity have been shown to activate regenerative mechanisms that can drive tissue repair, the company reports.

Learn more about RNA sequencing and how it benefits claims support in this exclusive podcast, sponsored by Genemarkers. Register now to listen; it's free.

[podcast] How RNA Sequencing Advances Claims Support

RNA sequencing is a newer, more dynamic approach than DNA sequencing to measure the effects of ingredients and products on skin. Rishabh Kala, Ph.D., of Genemarkers, explains its capabilities in this sponsored podcast. Listen now; it's free.

Using an oil blotting film to collect facial sebum, Kao can apply skin surface lipids-RNA monitoring technology to 'infer' skin and physical conditions such as pediatric atopic dermatitis and Parkinson's disease.

Kao's New Infant Sebum Testing Protocol Can Flag Atopic Dermatitis, Parkinson's Disease

The move is the start of Kao's expansion into health testing services.

In evaluating how different solvents may affect the rheology of personal care formulas, it is helpful to consider that different formulation types have distinct relationships between viscosity and elasticity depending on the factors generating their elastic properties.

How Natural Butylene Glycol Advances Market and Rheology Dynamics

Demand for sustainable ingredients in cosmetics and personal care is well-known. Here, a sustainable natural butylene glycol is described to advance this trend and its effects on viscosity and elasticity are assessed in five test formulas.

Like other markets, efficacy testing, including for cosmetics, is projected to have a substantial increase in revenue by 2027, largely due to pharmaceuticals and biotechnology making constant advancements in relation to public views and the pandemic.

Efficacy Testing Market Worth $423 Million by 2027

Like other markets, efficacy testing, including for cosmetics, is projected to substantially increase in revenue by 2027, largely due to pharmaceuticals and biotechnology making constant advancements in relation to public views and the pandemic.

The authors believe that adding the properties of a wide range of commercial sunscreens to the system database will increase the rate of appropriate sunscreen usage by customers.

AmorePacific, Hanyang Univ. Dynamically Visualize UV Dose on SPF-protected Skin

Work by AmorePacific and Hanyang University, Seoul, published in Skin Research & Technology, reveals a dynamic approach to visualize UV dose based on MED, weather, outdoor activity, etc., on SPF-protected skin.

The model accurately predicted skin permeability and the speed of the UHPLC method could classify it as a high-throughput approach.

Test Model Developed to Predict Skin Permeability of Compounds

A test model published in the Journal of Chromatography A uses retention on octadecyl, cholesterol-bonded and immobilized artificial membrane columns to accurately predict the skin permeability of compounds.

To prevent and repair UV-induced skin damage, a sustainable ingredient was developed from Sargassum vulgare, a brown seaweed that naturally evolved phlorotannins to defend against UV damage. The algae was fermented using a proprietary yeast to enrich this bioactive content; the resulting ingredient was tested as described here for skin benefits.

Brown Seaweed Ferment Propagates UV Damage Protection for Skin

To prevent and repair UV-induced skin damage, a sustainable ingredient was developed from Sargassum vulgare, a brown seaweed that naturally evolved phlorotannins to defend against UV damage.

The Dermial ingredient, a hyaluronic acid matrix ingredient for skin and beauty, delivers better results for skin health over standard hyaluronic acid (HA) in nutricosmetic form.

Bioiberica’s Dermial Nutricosmetic Outperforms Extracted and Fermented HAs

A pre-clinical in vitro study showed the Dermial hyaluronic acid (HA) matrix nutricosmetic increased type I collagen production by almost half. According to Bioiberica, this has not been seen with standard extracted or fermented HAs.

For multifunctional products such as moisturizing hand sanitizers, the sanitizer claim requires a significant reduction (2-3 log) of a microorganism population while the moisturizer claim requires data showing an increase in skin moisture.

Testing the Safety and Efficacy of Multifunctional Personal Care Products, A Primer

Multifunctional products may offer solutions to consumer challenges but as the needs of consumers grow more complex, so do their safety and efficacy testing. This article provides a primer on these considerations.

Eurofins Ct2203 Lead

Reduction of skin stress by CBD products: Aiming high above the competition

The use of cannabinoid products is growing in popularity. Formulate with cannabinoids confidently with effective technology development strategy from Eurofins – download a free brochure on CBD testing for safety and compliance.

Silicones are widely used as binders in pressed powders but growing consumer skepticism has prompted the use of alternatives. The aim of this study was to assess the efficacy of three plant-derived natural binders in obtaining optimal pressed powders, using dimethicone as a standard.

‘Pressed’ for Powders: Replacing Dimethicone with Plant-derived Alternatives*

The aim of this study was to assess the efficacy of three plant-derived natural binders in obtaining optimal pressed powders, using dimethicone as a standard.

In StratiCELL’s MicroBIOS Platform, the company can now colonize reconstructed epidermis with an IA1 phylotype strain of C. acnes.

StratiCELL Expands MicroBIOS Platform to Test C. acnes

In StratiCELL’s MicroBIOS Platform, the company can now colonize reconstructed epidermis with an IA1 phylotype strain of C. acnes that will elucidate interactions between the skin and its flora.

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