This month’s edition of C&T features solutions and ideas to protect the skin against key facets of the exposome. For UV protection, regulations (or a lack thereof), test methods and formulating challenges are outlined. Additionally, to reverse oxidative damage and inflammation, described is a dendrimer delivery of and the formulation of resveratrol; and fullerene nanoparticles in a similar capacity is reviewed. Then, the anti-inflammatory effects and safety of CBG is demonstrated, while the effects of sheep’s wool powder in an anti-pollution pigment proposal is tested. We hope this issue adds to the totality of your cosmetic R&D solutions.