Fragrance Allergen Calibration Mixes - Download FREE Technical Article


In 2017, the International Fragrance Association (IFRA) published a new method for testing 57 potentially allergenic fragrance compounds in response to an opinion by the European Scientific Committee on Consumer Safety (SCCS), which also proposed to correspondingly amend EC regulation No. 1223/2009.

This new analytical method has been developed to quantify the 57 fragrance substances and their relevant isomers at a concentration higher than 0.002% (20 mg/kg) in ready to inject fragrance materials and oils using Gas Chromatography with FID (GC-FID) or with Mass Spectrometry (GC-MS) detection. This new method allows the screening of complex fragrance mixtures for the presence of these chemically defined allergens.

By filling out the form you will receive a technical article about the use of flow-modulation comprehensive 2D GC/MS for the determination of allergens in fragrances. To ensure reliable and accurate results using this method, two certified reference material (CRM) mixes are used to cover the requested compounds. 

To learn more about our mixes and neat materials that are CRMs certified using quantitative NMR (qNMR) following ISO/IEC 17025 and produced under ISO 17034 accreditation, visit SigmaAldrich.com/fragrancestandards.


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