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Section: Testing > Safety/Stability

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Hazard List, Harmonization, Toxicity Tests and O'Malley Appointment: ECHA Updates

This ECHA update includes one addition to the hazardous chemicals list, two proposals for harmonized classification/labeling (eugenol and tetrahydrofurfuryl methacrylate), advice for toxicity test dosing and the appointment of Shay O'Malley.

BASF and Givaudan collaborated to develop and validate alternative animal testing methods, leading to the first toxicology testing strategy without animals that was adopted by OECD.

BASF and Givaudan Develop First OECD-Approved Animal Test Alternatives

The OECD has, for the first time, approved a non-animal strategy to assess skin sensitization based on three tests. In addition, the Kinetic Direct Peptide Reactivity Assay was approved to predict the intensity of reactions. All tests are the results of BASF/Givaudan joint efforts.

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Cosmetovigilance Connections: Safety and Concerns Over Light-cured Gel Nails

Cosmetovigilance is necessary for the prevention of potentially undesirable effects from cosmetic products. In relation, UV light used to cure gel manicures is one area with which the CTPA and British Society for Cutaneous Allergy are concerned.

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Letter to Editor Questions Benzophenone Study; Author and Industry Expert Respond

A Letter to the Editor in Chemical Research in Toxicology points to flaws in a study gaining recent attention and calling for the removal of octocrylene-containing sunscreens from the market. The author responds; as does an additional industry expert, David Steinberg.

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CIR Gives Certain Keratin, Polymers and More the OK for Safety

The Cosmetic Ingredient Review Expert Panel has made a safety determination on a number of chamomile, polymer, keratin and sulfate ingredients. Some are safe for use at certain levels while two HDI polymers still have insufficient data.

Vegetable-derived, mild and sustainable skin cleansing ingredients are in demand, and this has led to the development of new detergent structures.

Testing and Developing a Sugar-derived Surfactant Blend for Delicate Skin

Vegetable-derived, mild and sustainable skin cleansing ingredients are in demand, and this has led to the development of new detergent structures. Described here is a combination of two mild surfactants that fulfils these requirements using the concept of “interrupted soap” to impart mildness. Studies to verify the functional, sensorial and mild characteristics of the new blend are detailed.

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Highs and Lows of Skin Adherence: Simplifying Skin Substantivity, Part I*

The first in a series, this column reviews the role of substantivity in skin care, which allows penetrants to remain on skin. A case study on the potential dangers of substantivity's effects, when combined with certain ingredients, also is examined.

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7 Recent Recalls: Babygenics, Tom's of Maine, Amika, HiBAR and Others

From hair spray and repair cream, to tattoo ink, children's sunscreen, toothpaste and others, several products have been recalled in recent months due to safety hazards and regulatory non-compliance. Following is an overview.

For multifunctional products such as moisturizing hand sanitizers, the sanitizer claim requires a significant reduction (2-3 log) of a microorganism population while the moisturizer claim requires data showing an increase in skin moisture.

Testing the Safety and Efficacy of Multifunctional Personal Care Products, A Primer

Multifunctional products may offer solutions to consumer challenges but as the needs of consumers grow more complex, so do their safety and efficacy testing. This article provides a primer on these considerations.

While some (if not many) of these allegations may be unfounded or misguided, it underscores the critical role of safety and toxicity testing even under non-typical product use conditions.

Unilever, J&J, Olaplex and L'Oreal Still Treading Legal Waters Over Lilial, Benzene

Olaplex, Redken, OGX, Dove, Nexxus, Suave, Tigi and Tresemmé brands are still making headlines as they tread legal waters over alleged Lilial and benzene content. Following are recent updates.

The CTPA and the U.K. cosmetic industry wants to promote the use of new approach methodologies (NAMs) as alternatives to animal testing for these vital safety requirements under other chemicals legislation, especially UK Reach.

CTPA Convenes to Progress the Use and Regulatory Acceptance of Animal Testing Alternatives

The CTPA and the U.K. cosmetic industry wants to promote the use of new approach methodologies (NAMs) as alternatives to animal testing for these vital safety requirements under other chemicals legislation, especially UK Reach.

Microbiological test methods for w/o formulas have raised questions in terms of their suitability. They also require a more critical view of the results than other product types. This first article in a two-part series reviews the limitations of such methods and options for their optimization. It also critically observes to what extent test results provide relevant information for an appropriate safety assessment. Part II, in August 2022, will explore a holistic approach to more accurately assess microbiological safety.

Determining Preservative Efficacy in W/O Formulas, Part I: Test Performance and Limitations

Microbiological test methods for w/o formulas have raised questions in terms of suitability. They also require a more critical view of the results than other product types. This first article in a two-part series reviews the limitations of such methods.

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3D Skin Substrate Meets Speed, Complexity and ECM-based Research Needs

Researchers from the University School of Dental Medicine in Boston have published on a 3D skin equivalent model with high throughput potential and greater cellular complexity originating from human ECM.

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SCCS Deems Salicylic Acid Safe for Preservation and Cosmetics, Anti-acne Still a Question

Preservation, cosmetic ingredients and anti-acne care applications for salicylic acid were reviewed by the SCCS in its latest published opinion.

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IFSCC Winners: Hair Muscle Anti-aging in 4D, Vascularized Skin Model and Odor-inhibiting Fragrance

Next-gen imaging shows hair muscles prevent skin sagging. Advanced vascularized skin modeling predicts skin absorption. And, an olfactory receptor assay finds fragrances to inhibit odor production. These papers won top honors during the IFSCC Congress.

Test methods/tools, here, refer to in vitro, in vivo, ex vivo, in silico, etc., methods, tools, substrates, technologies, etc., developed for R&D purposes to support cosmetics and personal care product or ingredient claims; prove efficacy, safety and stability; etc. See who wins – join us!

Which Cosmetic Product Test Method/Tool, Device and Digital Tech Will Clinch C&T Allēs in 2024?

Which test method/tool, device and digital technologies will win C&T Allē Awards? Find out at our exclusive dinner on March 6, 2024, at the Biltmore, L.A. – alongside our captivating Beauty Accelerate event. Following are the contenders...

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J&J Talc Suit Tally: $6.48 B Offer, $11 B Reserves, $700 M to States — Plus New Class Action and Talc-Cancer Evidence

J&J's path through talc suits is long, winding and confusing. Here, we've mapped out payouts and recent twists and turns — including a new class action seeking damages and medical monitoring, and a recent study suggesting a talc-cancer association.

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