Scientists at The Estée Lauder Companies uncovered a new mechanism linking elevated sugar exposure in skin cells to visible and biological signs of skin decline. This research, published in the International Journal of Molecular Sciences, help deepen the understanding of systemic cellular responses to changes in skin.
According to the company’s press release, researchers used advanced in vitro models to show that sugar-induced glycation instigates a cycle of inflammation and cellular senescence. The impacted cells grew more slowly, moved less and lost their ability to regenerate. These findings suggest that reducing or clearing glycation may support healthier, more resilient skin.
“By identifying glycation as a cellular disruptor, this study opens the door to new strategies in adaptation science,” said Dr. Claude Saliou, senior vice president of advanced technologies and global clinical and consumer sciences at The Estée Lauder Companies. “Through industry-leading research that helps us better understand the cellular and systemic mechanisms responsible for responding to external influences and stressors on skin, we are continuing to advance transformative skin care innovation and create high-performing products that meet the needs of our consumers around the world.”
The company’s press release notes that ingredients such as antioxidants and autophagy activators work in inhibiting glycation. The company’s scientists will continue working to identify new ingredients and formulations to address these key signs of skin aging.
