Research in Journal of Cosmetic Dermatology was published that sought to investigate the potential benefits of a topically applied autophagy-activating peptide for the treatment of acne.
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This research is based on recent studies published that cited the important role of autophagy signaling in sebaceous lipogenesis and epidermal differentiation.
Researchers examined the clinical efficacy of the peptide through an 8 week, double‐blind, randomized, vehicle‐controlled study. The effects of the peptide on sebaceous lipogenesis were measured by fluorescence microscopic analysis. Autophagy signaling in human immortalized SZ95 sebocytes, normal human epidermal keratinocytes and 3D reconstituted skin was examined. The researchers also analyzed changes in skin surface lipid compositions.
In the clinical study, a reduction of closed comedones, skin surface lipids and trans‐epidermal water loss (TEWL) was observed in acne‐prone skin after autophagy‐activating peptide application. In addition, there was a reduction of squalene and increase in cholesterol in the skin after eight weeks of application.
Topical application of the peptide downregulated sebaceous lipogenesis and improved skin barrier function. The authors concluded, “Considering the important roles of sebum and skin barrier function in acne pathogenesis, autophagy activation might represent a new therapeutic option in early forms of acne.”
