Polyoxyethylene (20) sorbitan monolaurate (INCI: Polysorbate 20), is a ubiquitous nonionic surfactant employed in the formulation of countless cosmetic and personal care products. The use of polysorbate 20 is reported in 85%, i.e. 68 of 80, of the product categories listed in the Personal Care Product Council’s On-Line INFOBASE, indicating its versatility and utility in a variety of goods.1–2 It can function as a solubilizer, emulsifier, stabilizer, dispersing agent or a wetting agent, among other functions. Beyond personal care, polysorbate 20 has similar functions in the formulation and processing of pharmaceuticals, food and beverage products, agricultural chemicals and household and industrial cleaning products.
Polysorbate 20 is a complex mixture of laurate esters of sorbitol and sorbitol anhydrides (sorbitans), consisting predominantly of the monoester condensed with approximately 20 moles of ethylene oxide.1 The material generally conforms to the idealized structure shown in Figure 1—i.e., a four-arm, star-shaped oligomer of polyethylene glycol (PEG) grown from a sorbitan core with a laurate ester end-capping one of the PEG arms. This representative form of polysorbate 20 has an average molecular weight of 1,228 g/mol.