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Research on perfluorocarbons (PFCs) began before World War II but it was the 1942 Manhattan Project in the United States to develop the atomic bomb that led to methods of producing PFCs other than reacting fluorine with hydrocarbon. As a result, PFCs have been adapted for a number of industries including traumatic brain injury, sickle cell crisis pain, trauma, wound care, decompression sickness, acute respiratory distress syndrome, stroke, myocardial infarction, surgery, diabetes and cosmetics. Research on perfluorocarbons (PFCs) began before World War II but it was the 1942 Manhattan Project in the United States to develop the atomic bomb that led to methods of producing PFCs other than reacting fluorine with hydrocarbon. As a result, PFCs have been adapted for a number of industries including traumatic brain injury, sickle cell crisis pain, trauma, wound care, decompression sickness, acute respiratory distress syndrome, stroke, myocardial infarction, surgery, diabetes and cosmetics.