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Section: Testing > Safety/Stability

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Do Nanomaterials Penetrate Skin? EUON Commissions Review Study

The EUON commissioned a literature review to explore the potential dermal absorption of nanomaterials. Results found the materials rarely penetrate intact skin, except for ionic silver, but a more standardized approach to testing is needed.

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Comparatively Speaking: Inflammation vs. Allergy

Are you formulating for sensitive skin? Or is it really normal skin undergoing a typical inflammatory response? Where do allergic reactions fit in? In this edition of "Comparatively Speaking," Nava Dayan, Ph.D., explains.

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Here Comes the Sun Protection: ISO Test Methods

Our knowledge of the sun and its effects on skin has increased over the years, including the damaging effects of UVA and UVB light. Testing methods for UVA and UVB rays differ; the following is a review of the testing protocols of the European Union and United Kingdom. (Click through to the Digital Edition)

Revisions include adding “special cosmetics” and “cosmetics using new ingredients” to the key categories of sampling testing.

China Revises Cosmetic Sampling Testing Rules, Calls for Comments

The measures will focus on testing in children’s cosmetics, special cosmetics and cosmetics containing new ingredients. Measures are open to public comment through July 14, 2022.

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Beauty Giants Jointly Uncover Skin Absorption of Some 50 Compounds

Researchers from P&G, L'Oréal, Pierre Fabre Dermo-Cosmétique, Beiersdorf AG and the ADME Task Force of Cosmetics Europe have undertaken a massive in vitro assessment of some 50 compounds to determine their skin absorption and toxicity potentials.

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3D Skin Substrate Meets Speed, Complexity and ECM-based Research Needs

Researchers from the University School of Dental Medicine in Boston have published on a 3D skin equivalent model with high throughput potential and greater cellular complexity originating from human ECM.

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'Zapping' Sensitive Skin: Capsaicin Tests Show Embelia concinna Comforts Irritation

In previous work, a flavonoid-titrated active ingredient based on Embelia concinna was shown in vitro to calm and soothe sensory neurons stimulated with capsaicin. Here, those results are confirmed in vivo using a capsaicin stinging test with human volunteers.

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ZnO Nanoparticles Penetrate but Only Under These Conditions

Zinc oxide (ZnO) nanoparticles are a major component in sunscreens but their ability to permeate skin has remained undetermined. Recent work in Applied Biomaterials identifies the conditions under which they penetrate—notably, not in their nano form as they exist in sunscreens.

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MilliporeSigma’s Antioxidant Standards

These cosmetic standards are used as a vital step in ensuring product safety and performance.

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Research Reviews Non-penetrating Sunscreen Vehicles, Looks to Jojoba

Several "carriers for the future" were highlighted, such as lipid carriers, cyclodextrin derivatives, encapsulation approaches and non-penetrating sunscreens incorporating UV filters and jojoba oil conjugates.

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FDA Issues Draft Guidance for Topical Drugs

Contact dermatitis from topical drugs and human safety are the topics in a recently issued guidance document made available by the FDA. Comments are sought through May 8, 2020.

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Methanol Content and How to Test for it: FDA Guidance

The U.S. Food and Drug Administration has outlined a policy for companies to test alcohol (ethanol) or isopropyl alcohol for hazardous methanol content prior to their use in hand sanitizer products.

BASF and Givaudan collaborated to develop and validate alternative animal testing methods, leading to the first toxicology testing strategy without animals that was adopted by OECD.

BASF and Givaudan Develop First OECD-Approved Animal Test Alternatives

The OECD has, for the first time, approved a non-animal strategy to assess skin sensitization based on three tests. In addition, the Kinetic Direct Peptide Reactivity Assay was approved to predict the intensity of reactions. All tests are the results of BASF/Givaudan joint efforts.

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VIDEO: Gallagher Notes Innovation, Sustainability, Among Accomplishments

In a recent exclusive interview with C&T, Kevin Gallagher, Croda’s retiring president of personal care/actives, spoke about some of the significant accomplishments of his long career with Croda. See what he talked about with C&T’s Rachel Grabenhofer.

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[updated] FDA Oversight Becomes Closer to Reality for US Cosmetics

According to the bill's authors, it is supported by the leading cosmetic manufacturers and would give the FDA unprecedented authority. Editor's note: This report now includes CIR commentary.

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