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174 Results
Section: Testing > Method/Process
Event Coverage
IFSCC Awards Transfer Resistance, Gentle Touch, Psychological Anti-aging and More
From transfer-resistant cosmetics and scent-activated skin care, to a psychological approach to anti-aging, and a novel solid lipid nanoparticle + talc-based cosmetic excipient, the IFSCC 2021 Congress recognized some of the best and latest work in cosmetics research.
Method/Process
Preservative Efficacy Testing of Aqueous Cosmetics and Drugs without Counting Colonies
A miniaturized system using broth enrichment followed by either streaking on agar or fluorescence treatments can eliminate colony counting in the linear regression method of preservative efficacy testing.
Animal Alternatives
Non-animal Transdermal Diffusion Model Testing for Cosmetic Actives and Formulations
Experience the unmatched predictability of Strat-M membrane—a synthetic, non-animal based model* for transdermal diffusion testing that is predictive of diffusion in human skin without lot-to-lot variability, safety and storage limitations.
Method/Process
Determining Korean Consumers’ Degree of Exposure to Lipstick and Face Creams
This study describes methods used in a Korean study to calculate consumer exposure to lipstick and face creams. The average amount applied daily was estimated and compared with data collected by weighing containers before and after use. The data collected was 1.8 to 1.6 times greater than the estimate, so although the survey represented real use patterns, the actual data was more accurate.
Method/Process
Determining Korean Consumers’ Degree of Exposure to Lipstick and Face Creams
This study describes methods used in a Korean study to calculate consumer exposure to lipstick and face creams. The average amount applied daily was estimated and compared with data collected by weighing containers before and after use. The data collected was 1.8 to 1.6 times greater than the estimate, so although the survey represented real use patterns, the actual data was more accurate.
Animal Alternatives
Non-animal Transdermal Diffusion Model Testing for Cosmetic Actives and Formulations
Experience the unmatched predictability of Strat-M membrane—a synthetic, non-animal based model* for transdermal diffusion testing that is predictive of diffusion in human skin without lot-to-lot variability, safety and storage limitations.
Method/Process
Clinical Evaluation of a Zinc- and Copper-based Eye Area Anti-aging Complex
A zinc and copper complex generating biomimetic electricity on a physiological level is shown here to improve the signs of photoaging in preclinical and clinical studies. This complex was applied to the eye area to confirm its efficacy as an anti-aging treatment option with good skin tolerance.
Method/Process
‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging
Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.
Method/Process
Testing Tactics: How Sensory Testing Bridges the Gap Between Technology and Consumer Experience
This article delves into the role of sensory testing in the development of cosmetics for skin and hair. Its applications, methodologies and unique place in the innovation toolbox are highlighted, along with expert insights and journal article examples.
Efficacy
Path Uncovered to Create Dermal Papilla-like Cells and Advance Hair Follicle Growth
Researchers from a group of universities in China have uncovered an approach to convert dermal fibroblasts into dermal papilla cell-like cells to advance hair follicle regeneration.
Method/Process
‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging
Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.
Testing
Mitigating 'Maskne:' Boldo to Balance Sebum, Bacteria and Redness in Acneic Skin
Peumus boldus
(boldo) extract was tested for effects on sebum production,
S. aureus
growth and
C. acnes
lipase activity in vitro, as well as on skin redness in vivo. This work aimed to develop a natural ingredient to control sebum, inhibit microbes and their activity, and reduce redness in acne-αfflicted skin.
Literature/Data
Patent Picks—Microbe Separation, Emulsion Arrays and Salicylic Acid Delivery From Powder
Patent Picks are compiled by the editors from publicly available sources. This edition features processes for identifying microorganisms, forming emulsion arrays and delivering salicylic acid from powder.
Animal Alternatives
3D Skin Substrate Meets Speed, Complexity and ECM-based Research Needs
Researchers from the University School of Dental Medicine in Boston have published on a 3D skin equivalent model with high throughput potential and greater cellular complexity originating from human ECM.
Method/Process
A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations
This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.
Actives
Oak, Green Tea and Orange Derivatives to Disrupt JAK/STAT, NF-κB Irritation Pathways
Activation of NF-κB and JAK/STAT pathways in keratinocytes leads to the release of immunomodulating factors that sustain an amplification loop between the keratinocyte and infiltrating immune cell, leading to skin irritation. To disrupt this loop, two complexes, one based on oak and green tea extracts, and another on orange flavonoids, were developed and are shown here to immediately soothe skin.
Method/Process
Kao and Tsukuba Univ. Scientists Devise Technique to Visualize the Depths of Skin Wrinkling
Joint research from Kao Corp. and Tsukuba University aims to uncover the depths of structural changes in skin related to wrinkling utilizing an imaging technique that algorithmically localizes backscattered light from skin into layers.
Actives
Narcissus Tazetta
and
Schizandra Chinensis
to Regulate ‘Youth Gene Clusters’—An In vitro Analysis
A blend of
Narcissus tazetta
bulb and
Schizandra chinensis
fruit extracts was developed for anti-aging benefits and tested for efficacy on a human skin equivalent. Results indicate it regulates the functions of youth gene clusters by increasing the activities found in younger skin and reducing the activities found in aging skin specific to structure, hydration, cellular proliferation and pigmentation.
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