Chanel is spying on skin. In a new patent, the company explains how microRNAs (miRNAs) modulate gene expression in various biological and pathological processes, such as cellular senescence and organism aging.
As such, products or active agents that affect miRNA expression, in turn preventing, reducing or even inhibiting cellular senescence, particularly of the fibroblast, are desired. The company's patent discloses a method to identify such agents.
Inhibitors of micro-RNAs for anti-aging benefits in skin
Publication date: Feb. 14, 2017
U.S. Patent 9568467
Assignee: Chanel Parfums Beauté
The process involves:
a) bringing at least one test compound into contact with a sample of fibroblasts;
b) measuring the expression or activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts; and
c) selecting the compounds showing at least a 20%, preferably 40% or more, activity in comparison with untreated fibroblasts.
Further details are disclosed in the complete patent listing.