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Patent Pick: Putting Corynebacterium to Work for Skin Care

Contact Author Rachel Grabenhofer
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Skin conditions such as inflammation, redness, hyperpigmentation and wrinkling are the focus of a new patent application by Access Business Group. Here, the company put Corynebacterium species to work to rebalance these ailments via the skin microbiome.

The skin microbiome typically refers to the microorganisms that reside on human skin, many of which are bacteria found mostly in the superficial layers of the epidermis and the upper parts of hair follicles, according to the patent disclosure. The skin microbiome is usually non-pathogenic, and commensal or mutualistic in nature.

Native bacteria can prevent transient pathogenic organisms from colonizing the skin surface by competing for nutrients, secreting chemicals to defend against them or stimulating the skin's immune system. Unfortunately, some resident microbes may also cause irritant or other skin conditions.

As such, there is a market opportunity to improve the skin microbiome for various effects; this was the focus of the present patent application.

The Literature

Method and topical composition for modification of a skin microbiome
U.S. Patent Application 20190160117
Publication date: May 30, 2019
Assignee: Access Business Group

Disclosed in this patent is a method for modifying the skin microbiome that comprises administering a topical composition to skin including a population of microorganisms, a component obtained from the population of microorganisms, or a combination thereof.

The population of microorganisms is generally a Corynebacterium species, which has previously been implicated in relation to skin aging. Here, the Corynebacterium species comprises, for example, an at least ~90%, optionally at least ~97%, sequence identity to a 16S rRNA sequence (see SEQ ID NO: 1, outlined in the patent application).

Further skin conditions that may reportedly be reduced, slowed and/or prevented via this method include, but are not limited to: acne, psoriasis, rosacea, eczema, vitiligo, dermatomyositis, acitinic keratosis (age spots), seborrheic keratoses, dermatitis and combinations thereof. In addition, in various embodiments, the method and/or topical composition is useful for soothing and calming the subject's skin.

Patent application accessed on June 3, 2019

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