A recent study published in a MedRxIV preprint describes a 56-day randomized, double-blinded and placebo-controlled clinical assessment of scalp health and hair growth parameters after the application of an essence incorporating Centella asiatica extracellular vesicles (EVs) and recombinant growth factors (rIGF-1 and rFGF-7).
Conducted in 60 participants, the study compared five groups using different formulations, including a placebo and variations of the base formula.
Key Research Findings
According to the full open access article, key findings revealed the combination of C. asiatica EVs and growth factors significantly improved scalp health and hair growth parameters, such as sebum content, hair density, thickness and reduced hair loss, compared with the placebo.
The group using the full formulation (including EVs and growth factors) demonstrated the most significant improvements, with increases in:
hair density by 23.9%
hair thickness by 27.9 μm, and
hair length by 3.5 cm by Day 56.
Additionally, this group showed a 63.6% reduction in hair loss and an average 59% decrease in sebum production.
In the Mix
C. asiatica EVs, which are rich in bioactive compounds, combined with long-acting growth factors to enhance hair follicle regeneration, prolong the anagen phase and improve scalp conditions, the authors report. What's more, the inclusion of caffeine and panthenol in the base formula contributed to follicular stimulation and hydration.
This research underscores the potential of combining plant-derived bioactive compounds with advanced growth factors for effective, non-invasive scalp care.
