Interpersonal Hormone Transfer and Cosmetic Contact Allergens

In clinical medicine, percutaneous penetration has become a diagnostic reality, with evidence of the unintentional transfer of active gender hormones, i.e., estrogen and testosterone, from dosed to unknowing individuals occurring in clinical trials via interpersonal contact.1–4 Transfer depends on many factors, such as type of exposure, amount of transdermal hormone applied, number of exposures, applied area, transfer area, timing and frequency of contact.5 This unintentional transdermal hormone transfer may cause a clinically significant hormone imbalance and side effects such as cardiovascular events or masculinization in adults and precocious puberty or virilization in children.5–10

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