Patent Picks—Lipstick Gloss, Probiotics, Anti-acne, Cosmetic Films, Heat Shock Proteins and More for Skin

Patent Picks are compiled by the editors from publicly available sources. This edition features inventions related to cosmetics and skin care, including heat to improve lipstick gloss and probiotics for oily skin, as well as heat shock proteins, FABACs, improved vitamin C derivatives, an anti-acne blend, a skin-smoothing cosmetic film and a photo-initiated filler from the medical field.

Heat-treating lipstick for improved gloss
U.S. Patent 8945524
Publication date: Feb. 3, 2015
Assignee: L'Oréal

This invention relates to the application of a cosmetic product to the skin or the lips that is initially in a solid form, such as a stick, and treated with heat to procure a glossy effect. According to the inventors, lipsticks have been packaged as sticks for direct application to the lips and therefore must meet contradictory requirements. On one hand, they must satisfy mechanical requirements to glide on and remain stable during application. On they other hand, they must transfer to the lips and remain comfortable during application, as well as a sufficiently deposit the correct quality to the lips.

Thus, this invention describes a method for making up non-fibrous human keratin material, particularly the skin or the nails, that involves bringing the outer surface of a solid cosmetic composition having a temperature-sensitive dynamic rub coefficient, into contact with or near a heating device. In this manner, the dynamic rub coefficient of only the outer surface of the composition is lowered, which is then applied to the area to be treated. Example formulations are provided.

Microorganisms to treat oily skin
U.S. Patent 8951775
Publication date: Feb. 10, 2015
Assignee: L'Oréal and Nestec SA

There remains a need for active agents that are capable of exerting a beneficial cosmetic or therapeutic action on oily skin to re-establish the eco flora, that are also pleasant and comfortable to use, thus promoting compliance. Described in this patent is the cosmetic use of at least one probiotic microorganism and/or fraction thereof and/or metabolite thereof as an agent for treating oily skin and the associated skin disorders. Specifically, those of the Lactobacillus sp. and/or Bifidobacterium sp. genus are named. The inventors have noted, in fact, that such a microorganism is found to be effective for both the treatment and prevention of disorders associated with oily skin.

Heat shock proteins for anti-aging, wound healing and anti-cellulite
WIPO Patent Application WO/2015/020499
Publication date: Feb. 12, 2015
Assignee: Regeron, Inc.

Disclosed in this patent are the liposomal and/or nano-liposomal encapsulated heat shock proteins HSP90a, HPf polypeptide (115 aa) and novel polypeptides HPf ΔC1 (101 aa) and HPfΔC2 (87 aa), as well as methods for manufacturing, preparing and using the compositions. Methods for producing large amounts of recombinant HSP90a, HPf polypeptide, HPf ΔC1 or HPfΔC2 polypeptide, using expression vectors and transformed cell lines, also are described. Their topical use improves skin conditions such as atopic dermatitis, wrinkles, skin elasticity and hyperpigmentation. Liposomal preparations for enhancing wound healing and suppressing subcutaneous fat cell differentiation are discussed as well.

Bile acid-fatty acid conjugates for anti-aging
WIPO Patent Application WO/2015/019358
Publication date: Feb. 12, 2015
Inventors: N Dayan and A Baharaff

Fatty acid bile acid conjugates (FABACs) were hypothesized, in a recent article, to provide anti-aging and anti-acne applications. This invention discloses their use for anti-aging benefits, including compositions for preventing, attenuating or treating skin aging and symptoms related thereto. The activity of FABACs is based on their capability of reducing gene expression levels of keratin 10 and keratin 1 in skin fibroblasts, thus reducing keratinocyte differentiation. The invention is further based on the discovery that administration of FABACs does not result in a significant effect on the viability of epidermal cells, in contrast to the administration of retinoids.

Improving vitamin C complexes for skin care
U.S. Patent Application 20150045426
Publication date: Feb. 12, 2015
Inventors: P. Couvreur, F. Zouhiri, R. Gref and D. Desmaele

The aim of this invention is to propose novel derivatives of vitamin C that penetrate into the skin more easily, stimluate the expression of type III collagen and glycosaminoglycans, and display increased stability against oxidation. The inventors found that the covalent coupling of ascorbic acid with at least one specific molecule can provide these effects. Specified is a complex formed of at least one molecule of 5-(1,2-dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one or a derivative, covalently bonded with at least one hydrocarbon radical. This invention also aims to favor formulation both in an aqueous and oily media and can be applied to improve skin flexibility, hydration, thickness and elasticity.

Naphthoic acid, benzoyl peroxide and a film-former for anti-acne
U.S. Patent 8952066
Publication date: Feb. 10, 2015
Assignee: Galderma Research & Development

Disclosed in this patent are pharmaceutical/cosmetic compositions for topical application notably for the treatment of Acne vulgaris. These include at least one naphthoic acid compound, benzoyl peroxide and at least one film-forming agent. Said compositions are more stable and less irritating than those of the prior art. According to the inventors, film-forming ingredients may improve the tolerance of skin to the benzoyl peroxide and naphthoic acid compounds.

Skin- and wrinkle-smoothing films
U.S. Patent Application 20150037380
Publication date: Feb. 5, 2015
Inventors: A.L. Newman, N. Lorincz Leppla, L.E. Breyfogle, G.G. Guay, D.E. Wilson and J.M. Zukowski

According to these inventors, there is a continuing demand for compositions that can improve the appearance of skin, i.e., reduce the appearance of wrinkles, that also balance the correct amount of skin contraction, film flexibility, lack of film whiteness, contraction resiliency and compatibility with other cosmetic products and do not cause skin irritation. These and other improvements over prior art are provided by this present invention. A skin-smoothing film is described, comprising sodium silicate, polyvalent silicate and water. This film can have a contraction value from about 30% to 160%, and the film thickness is preferably from about 10 microns to 40 microns.

Photo-initiated tissue filler
U.S. Patent 8945624
Publication date: Feb. 3, 2015
Assignee: The Johns Hopkins University (Baltimore, MD, US)

From the medical field, this potentially transferable patent describes visible light-activated polymer cosmetic filler preparations. In some embodiments, the composition comprises a conventional polymeric material such as hyaluronic acid, together with a modified, crosslinkable polymer, such as PEG or PEODA. This combination permits the formation of cross-links within the polymer matrix in situ upon exposure to a visible light source, such as an IPL device. Such preparations provide for a more stabilized composition that is contourable during gelation. Compositions of the present disclosure may further comprise a cell, or encapsulated cells, tissues and/or engineered cells and tissues.

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