Peptidomimetics for Cosmetic Applications

Bioactive peptides are capable of inducing biological responses by stimulating cell surface receptors, inhibiting protein-protein interactions, inducing protein conformational rearrangements, inactivating enzymes, regulating gene expression levels, etc. However, their inherent proteolytic instability, poor transport properties into the bloodstream and across the blood-brain barrier, rapid excretion through the liver and/or kidneys, and reduced efficacy due to inherent structural flexibility make them poor candidates for systemic drug delivery molecules.1

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