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Intra- and Inter-Individual Differences Sensitive Skin

Contact Author F. Distante, L. Rigano, R. D'Agostino and A. Bonfigli, Institute of skin and Product Evaluation; E. Berardesca, San Galicano Dermatological Institute
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Skin reactivity to various stimuli displays regional differences according to body site as has been widely documented. These regional differences have been attributed principally to two factors. The first is anatomical differences in skin structure. The second is skin biophysical properties such as barrier function, skin permeability and vascular response to topically applied substances. These findings imply that the results of studies on irritation and cosmetic evaluations performed on different body areas cannot be easily correlated.

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