Grape Stem Cells for Free Radical Protection


Mibelle Biochemistry protects and maintains the activity of epidermal stem cells with an powder based on the stem cells of a rare red-flesh grape tolerant to strong UV radiation. PhytoCellTec Solar Vitis (INCI: Vitis Vinifera (Grape) Fruit Cell Extract (and) Isomalt (and) Lecithin (and) Sodium Benzoate (and) Water (aqua)) is said to help the skin stem cells maintain their stem cell characteristics and protect the skin stem cells against UV stress.

According to the company UV radiation is responsible for 80% of skin aging. This is due to toxins and free radicals being generated by UV in the skin. The active delays senescence of essential cells, and fights photoaging.

A rare grape cultivar, Gamay Teinturier Fréaux, was selected by the company for use in the active. This cultivar reportedly has red flesh and juice due to a high anthocyanin content. Anthocyanins are powerful antioxidants and free radical scavengers.

Stem cells from this cultivar were obtained using the company's PhytoCellTec technology. The  technology involves wounding part of the plant to induce the formation of callus cells. This wound-healing tissue consists of dedifferentiated cells that are stem cells. Callus cells are harvested and cultivated in suspension and a bioreactor system enables large scale production. To obtain the active, the stem cells are harvested and homogenized at 1200 bar together with phospholipids to encapsulate and stabilize oil- and water-soluble components into liposomes. The resulting extract is carefully sprayed onto a powder based on isomalt. These grape stem cells contain special epigenetic factors and metabolites that are able to protect human skin stem cells against UV radiation.

The company recommends the active for advanced stem cell formulas, face and body care that protects the stem cells, and daily skin care to prevent photoaging. The active is recommended at 0.4-1%.

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