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Recent in Testing (page 29 of 33)

Hair Color Vibrance Factor to Characterize Shine and Color Intensity*

May 6, 2013 | Timothy Gao, PhD; Peter Landa; Regan Tillou; and Kevin Gallagher, Croda Inc.

To evaluate the comprehensive effects of shine and color intensity in hair, a hair color vibrance factor has been developed to enable new claims for hair dye formulas and after-dye treatments. Experimental results described here show how varying the ingredients in shine spray and hair dye formulas affect this factor and correlate with subjective panelist assessments.

Mature and Immature Corneocyte Detection Force Distance Curves vs. Microfluorometry

May 6, 2013 | Anthony J. Ribaudo, Textile Research Institute (TRI) Princeton

Here, the author compares two methods to determine the maturity of corneocytes based on their cross-linking that could be used to evaluate the anti-aging effects of molecular agents. The first utilizes microfluorometry, while the second involves F-D curves generated via contact mode AFM. Both methods successfully detected differences in mature or immature corneocytes with 95% confidence.

Testing Tactics—Consumer vs. Scientific Language: Relating In vivo to In vitro

May 6, 2013 | Trefor Evans, PhD, TA Evans LLC

It should perhaps go without saying that consumer products are sold using consumer language. Market researchers and consumer scientists spend a great deal of time studying their target audience and learning this vocabulary, which subsequently allows the recounting of product benefits in the same terminology.

Evaluating Essential Oils in Cosmetics: Antioxidant Capacity and Functionality

May 1, 2013 | P. Ziosi, S. Manfredini, S. Vertuani, V. Ruscetta, M. Radice and G. Sacchetti, Università Degli Studi di Ferrara; and R. Bruni, Università Degli Studi di Parma

In the present work, the antioxidant capacities of three essential oils derived from basil and thyme were evaluated using a photochemiluminescence (PCL)-based assay. In addition, since the base formulation can affect the antioxidant activity of oils contained therein, ingredient interactions within final formulations were investigated.

Evaluating 1,3-Propanediol for Potential Skin Effects

May 1, 2013 | Leigh A. Belcher, Carl F. Muska, PhD, and Joseph W. DeSalvo, DuPont

In the present article, the authors assess the skin irritation and sensitization potential of 1,3-propanediol (INCI: Propanediol). Results in animals and humans by acute or repeat exposure support a low potential of skin reactivity for the material. In addition, the skin reactivity potential in humans was found to be lower with 1,3-propanediol than 1,2-propanediol (INCI: Propylene Glycol).

Predicting the Percutaneous Penetration of Cosmetic Ingredients*

Apr 24, 2013 | Sara Farahmand, PhD, University of Cincinnati College of Pharmacy; and Howard I. Maibach, MD, PhD, University of California School of Medicine

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

Microfluidic Testing for LLNA Replacement

Apr 19, 2013 | Katie Schaefer, Cosmetics & Toiletries magazine

The Hurel Corp. has developed a microfluidic, non-animal alternative to the LLNA and it has partnered with L’Oréal to make this approach a reality—in the form of a chip.

Mechanisms of Tape Stripping and Protein Quantification*

Apr 19, 2013 | Ali Alikhan, MD, and Howard I. Maibach, MD

In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.

A Rapid and Sensitive In vitro Method to Ascertain Antioxidative Capacity*

Apr 17, 2013 | Hongbo Zhai, MD, and Howard I. Maibach, MD, University of California San Francisco

New methodologies have recently been developed to determine antioxidant effects but they often require extensive training and are time-consuming to conduct. In the present article, however, the authors describe an in vitro method to detect the effects of antioxidant-containing formulations using photochemiluminescence to provide rapid, accurate and sensitive measurements.

Researchers Develop Non-animal, Dendritic-based Sensitizer Test

Apr 16, 2013

Researchers from the University of Aveiro, the University of Coimbra and the University Hospital of Coimbra have developed a dendritic cell-based test for skin sensitizers that can serve as an alternative to animal testing.

Beiersdorf Researcher Develops Skin Imaging Method for Analysis

Apr 9, 2013

Beiersdorf has created a new method of skin analysis to help it develop new skin care products.

A High Throughput Method to Predict Skin Penetration and Screen Topical Formulations

Apr 4, 2013 | Konstantin Tsinman, PhD, Pion Inc.; Bálint Sinkó, PhD, SinkoLAB Scientific Bt.

This work studies the applicability of a 96-well-based skin-mimetic artificial membrane permeability model to differentiate between topical pharmaceutical and cosmetic formulations. Results are compared with data obtained from in vitro Franz cell permeability measurements and reveal the applicability of this method to assess cosmetic formulation permeation and speed the discovery process.

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