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248 Results

Section: Testing > Method/Process

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Olfactory Receptors Could Indicate UV, Inflammatory Skin Damage

Research published in the International Journal of Molecular Sciences shows the expression of olfactory receptors in skin could be used to indicate UV and inflammation-induced barrier damage.

Modeling UVB-induced Formation of Photoproducts in Human Keratinocytes

The authors describe a model to visualize the appearance of cyclobutane-pyrimidine dimers in the nuclei of normal human keratinocytes after UV irradiation. These dimers are one of the principal agents in DNA damage. The model can be used to assess the effect of a cosmetic ingredient on the formation of direct UV-induced lesions to DNA.

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In Vitro and In Vivo Offered for Sunscreen Testing

Laboratoire Dermscan and HelioScreen Labs are combining their skills to offer a complete new in vitro / in vivo service in the field of sunscreen testing.

Comparing Methods to Measure Porcine Skin Integrity In Vitro

To confirm the integrity of porcine ski prior to penetration tests, published studies show that measuring transepidermal water loss, transdermal electrical resistance or caffeine penetration levels are often chosen techniques. New results demonstrate that

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Moisturizer Penetration in Skin Revealed via Low-coherence Inferometry

Research published in the Russian journal Engineering describes a method to measure the penetration of gel moisturizers in skin in vivo via low-coherence interferometry.

Interpretation of SPF In vivo Results: Analysis and Statistical Explanation

Methods for determining SPF in vivo are based on a biological response by human skin. To overcome intrinsic variation in these methods, large numbers of volunteers and statistics are required; however, these concepts are often poorly understood or worse, misinterpreted. This article discusses how these values should be interpreted and explains what they mean to formulators.

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Interpretation of SPF In vivo Results: Analysis and Statistical Explanation

Methods for determining SPF in vivo are based on a biological response by human skin. To overcome intrinsic variation in these methods, large numbers of volunteers and statistics are required; however, these concepts are often poorly understood or worse, misinterpreted. This article discusses how these values should be interpreted and explains what they mean to formulators.

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Fighting AGEs Formation: Upcycled Artichoke Inhibits Glycation, Increases Skin Firmness

Upcycling organic waste into cosmetics has been of interest for the growing sustainability trend—and artichoke, in particular, demonstrates anti-aging activities. Described herein is the development of an upcycled artichoke byproduct, which was tested for effects on skin glycation and elasticity.

Translating Data into Claims and Interpreting Regulations: Science vs. Marketing

Substantial evidence, which the FDA requires to support claims for drugs, is applicable to personal care, especially considering the pharmaceutical direction products have taken. The present article considers whether the industry is benefiting from marketing without assuming the responsibility for potential effects. In addition, it considers the limitations of in vitro and in vivo test models.

Dermal Absorption Guidelines for Cosmetic Ingredients: An In Vitro Method

Ex vivo skin absorption studies measure the penetration and permeation of a compound to assess its safety, and can assist the formulator in increasing product efficacy and reducing toxicity. This review analyzes the currently available guidelines published by four major regulatory organizations to clarify important milestones in study design, data analysis and interpretation.

Translating Data into Claims and Interpreting Regulations: Science vs. Marketing

Substantial evidence, which the FDA requires to support claims for drugs, is applicable to personal care, especially considering the pharmaceutical direction products have taken. The present article considers whether the industry is benefiting from marketing without assuming the responsibility for potential effects. In addition, it considers the limitations of in vitro and in vivo test models.

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CBD in Effect: Correlating In vitro and Ex vivo Skin Benefits

Primary biological functions of the skin barrier, immune system, lipids, free radicals and extracellular matrix are, in fact, impacted by CBD, as a poster and podium presentation by Genemarkers at SCC Annual demonstrated.

Properties of a Pseudoceramide Multi-Lamellar Emulsion In Vitro and In Vivo

Tests of a pseudoceramide multi-lamellar emulsion formulation for its stability and its assistance to barrier recovery in vivo on damaged skin suggest dermatologic and cosmetic possibilities.

Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.

Influence of Skin Diffuse Reflectance on Sun Damage and Ingredient Efficacy Measurements

Current in vitro methods to assess photostability and antioxidant activity do not account for the diffuse reflectance of skin. Described here is an in vitro test that addresses this variable, mimics end-use product conditions and models photodamage processes. The approach is employed to determine the efficacy of an antioxidant from the Camellia sinensis (tea) plant.

Rob Travis' primary responsibility will be leading the sales efforts for Stream Sensing.

In-line Rheometry Tech in Demand, Travis to Lead Stream Sensing Sales

Stream Sensing Ltd. reports it has appointed Rob Travis as director of business development to respond to growing demand for automated in-line rheometry sensing to optimize fluid processing for personal care, pharma and other industries.

‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging

Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.

‘How Did THAT Get in There?’ Identifying Particulate Contamination in Products and Packaging

Particulate contamination and discoloration may occur in products due to foreign materials introduced via raw materials or during the manufacturing process. Agglomeration or reactions between ingredients and packaging components also are possible sources. The identification of contaminants and their origin, described here, is therefore critical so that future incidents can be prevented and safety or regulatory concerns can be addressed.

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