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87 Results

Section: Testing > Method/Process

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Nature and Estée Lauder to Honor Up-and-coming Female Researchers

In a new partnership, Nature Research, publisher of the industry-renowned journal Nature, and multinational cosmetics giant The Estée Lauder Companies will present early-career female scientists with awards for innovating and inspiring science.

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Comparatively Speaking: The INCI Names vs. Properties of Silicone Surfactants

Surface tension is a ruling factor in the formulator's world. In this edition of "Comparatively Speaking," Tony O'Lenick explains its influence on foam and wetting; he also demonstrates how little the INCI name reveals about a material's properties.

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Scale-up Success: Untapping the Potential of Computational Fluid Dynamics

Scaling up cosmetic products to manufacturing facilities is a common cause of formulation difficulties. Computational fluid dynamics offer a means to model and troubleshoot potential problems in advance, and could become a standard tool to reduce production costs.

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2 Winners and 4 Finalists Shine in 2023 Cosmetic Victories Competition

Cosmetic Victories finalists included a human skin model, natural senolytic ingredient, photoactivable algae derivative for anti-acne effects, a palm oil alternative and both in vitro sunscreen ecotoxicity and contaminant testing. See who won.

*Depiction only; not the actual substrate

Researchers Engineer Hydrogel-based Skin Substitute Complete with Rete Ridges

According to the authors, this work provides a simple and powerful way to mimic the structures of human skin and can contribute to skin tissue engineering and wound healing research.

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Stroke of Genius: Successive Combing Force Yields Realistic Conditioning Results

Combing tests are widely used to characterize the conditioning performance of products at one snapshot in time. A successive combing force device was designed to more realistically simulate the entire shampooing and conditioning process. Here, the authors put it to the test.

This review first assesses the methods used to quantify 1,4-dioxane in surface water and drinking water, then extends the assessment to more complex commercially available products.

[updated] How to Ensure Cleansers Comply with Growing 1,4-Dioxane Regulations

A review in the Journal of Surfactants and Detergents explored means of measuring 1,4-dioxane levels in cleansers in order to comply with increasing ppm restrictions set by U.S. states. In this update, industry expert Tony O'Lenick adds context.

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Is Your Microbiology Lab FDA-compliant? Part I: Personnel, Facilities and Equipment

This two-part article provides an overview of areas relevant to the U.S. Food and Drug Administration’s (FDA’s) inspection of cosmetic microbiology laboratories. Part II will appear in our July 2018 edition.

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3D Skin Substrate Meets Speed, Complexity and ECM-based Research Needs

Researchers from the University School of Dental Medicine in Boston have published on a 3D skin equivalent model with high throughput potential and greater cellular complexity originating from human ECM.

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Modeling and Targeting Cell Communication, Senescence and Immunoevasion to Support Skin Longevity

The present work sought to develop in vitro models to study the mechanisms of key hallmarks of aging: cellular communication, senescence and immunoevasion. The models were then used to test the efficacy of natural actives targeting these mechanisms.

Clinical Evaluation of a Zinc- and Copper-based Eye Area Anti-aging Complex

A zinc and copper complex generating biomimetic electricity on a physiological level is shown here to improve the signs of photoaging in preclinical and clinical studies. This complex was applied to the eye area to confirm its efficacy as an anti-aging treatment option with good skin tolerance.

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Is Your Microbiology Lab FDA-compliant? Part II: Cultures, Growth Media, Reagents and Testing

This two-part article provides an overview of areas relevant to the U.S. Food and Drug Administration’s (FDA’s) inspection of cosmetic microbiology laboratories. Part 1 covered personnel, facilities and equipment, test materials and procedures, and documentation. Part 2 addresses microbial cultures and growth media, biochemical reagents, test procedures and more.

Comparison of Age Determination by Three Evaluation Methods: Self-assessment, Expert Grader and Naïve Grader

This exploratory study investigates how consumers perceive age, using objective and subjective approaches. Results of this study suggest that when a subjective approach is implemented for age determination, subjects affix their emotions to the evaluation. The reverse logic was applicable for the expert and naïve grader methods, as grader results appeared more neutral than the self-assessment.

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Comparison of Age Determination by Three Evaluation Methods: Self-assessment, Expert Grader and Naïve Grader

This exploratory study investigates how consumers perceive age, using objective and subjective approaches. Results of this study suggest that when a subjective approach is implemented for age determination, subjects affix their emotions to the evaluation. The reverse logic was applicable for the expert and naïve grader methods, as grader results appeared more neutral than the self-assessment.

Dermagenetics

The advent of the complete transcribing of the human genome will forever alter our perceptions of skin care, medicine and nutrition. This column is edited by Lawrence A. Rheins, PhD.

Enhancing, Measuring Skin Penetration

Skin penetration is of great interest to personal care formulators for many reasons. Following are a few recent findings.

Testing for Penetration of the Skin Barrier

The skin barrier is described, after which tests and case studies illustrate how to show if actives and other ingredients have or have not penetrated the skin barrier.

Predicting the Percutaneous Penetration of Cosmetic Ingredients

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

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