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Evaluating 1,3-Propanediol for Potential Skin Effects

In the present article, the authors assess the skin irritation and sensitization potential of 1,3-propanediol (INCI: Propanediol). Results in animals and humans by acute or repeat exposure support a low potential of skin reactivity for the material. In addition, the skin reactivity potential in humans was found to be lower with 1,3-propanediol than 1,2-propanediol (INCI: Propylene Glycol).

Predicting the Percutaneous Penetration of Cosmetic Ingredients

While previous algorithms for predicting the skin absorption of permeants was based on in vitro data, the present article proposes a quantitative structure-activity relationship (QSAR) model based on in vivo human data. Here, a set of human in vivo data is described that provides entry into predicting the penetration of cosmetic ingredients.

Testing in Cosmetic Valley

Raman spectroscopy and fringe projection are a few of the methods that have revolutionized the objectification market.

Is Cosmetic Science Really "Bad"? Part IV: How Scientific is Cosmetic Science?

Six questions from Michael Shermer’s Baloney Detection Kit have been discussed in this series. The results were not flattering for cosmetic science (read: cosmetic scientists) but cosmetic science did not score badly on all points. Questions seven and eight, described here, discriminate true science from borderland science and non-science or nonsense.

Mechanisms of Tape Stripping and Protein Quantification

In this article, several methods to quantify the protein collected by tape stripping are described, including traditional gravimetric methods as well as novel colorimetric and visible spectroscopic techniques. Further, one colorimetric method is described to effectively determine the keratolytic efficacy of various materials in vivo, suggesting additional roles for this method.

Translating Data into Claims and Interpreting Regulations: Science vs. Marketing

Substantial evidence, which the FDA requires to support claims for drugs, is applicable to personal care, especially considering the pharmaceutical direction products have taken. The present article considers whether the industry is benefiting from marketing without assuming the responsibility for potential effects. In addition, it considers the limitations of in vitro and in vivo test models.

A Rapid and Sensitive In vitro Method to Ascertain Antioxidative Capacity*

New methodologies have recently been developed to determine antioxidant effects but they often require extensive training and are time-consuming to conduct. In the present article, however, the authors describe an in vitro method to detect the effects of antioxidant-containing formulations using photochemiluminescence to provide rapid, accurate and sensitive measurements.

Researchers Mimic the Lymphatic System in Animal Alternative Chip

A chip created by L'Oréal and Hurel Corp. is designed to replace the local lymph node assay, a test often performed on cosmetic raw materials. In addition to saving animals, the chip is also said to be less expensive than animal testing. Hurel developed the working microfluidic portion of the chip.

Strong, Self-healing Hydrogel Created for Tissue Engineering

Researchers from the University of Tokyo have created a strong, self-healing hydrogel with applications in tissue engineering and drug delivery. The material incorporates a binder made from long chains of polyethylene glycol, an ingredient commonly used in skin care.

Updated Modeling and Simulation Platform for Chemists

A new software platform has been designed to improve the efficiency and effectiveness of chemical and materials research to increase research productivity and decrease time-to-innovation.

Webinar Focused on Cell-based Assays

BD Biosciences is hosting a webinar dedicated to cell-based assays. Elizabeth Abraham, PhD, a research scientist at BD Biosciences, will discuss the applications for the company's BD PureCoat surfaces.

In the Land of the Blind: Applying a Single-blind Study to Finished Products

Following positive feedback from a previous column on the placebo effect, Wiechers readdresses clinical study design in relation to cosmetic claim substantiation—this time discussing when to perform double-blind studies and when to perform single-blind studies.

Genetic Test for Alopecia Approved in Europe

The HairDX Genetic Test for Hair Loss, a genetic baldness test manufactured by HairDX LLC, is now available as a CE Marked product under the European In Vitro Diagnostic Directive.

Laser beams

Lasers to Improve Acoustic Imaging

US Naval Research Laboratory scientists are developing a technology using flashes of laser light to create underwater sound, which could improve acoustic imaging.

Photoaging and Photodocumentation

Techniques to photograph or image skin photodamage have reached new levels of sophistication. This survey discusses clinical grading, light imaging techniques, video-microscopy and three-dimensional in vivo measuring systems.

ECVAM Calls for Testing Experts

The European Centre for the Validation of Alternative Methods (ECVAM) is renewing its scientific advisory structure and is calling for life sciences experts interested in joining its ESAC or EEP groups.

Comparing Methods to Measure Porcine Skin Integrity In Vitro

To confirm the integrity of porcine ski prior to penetration tests, published studies show that measuring transepidermal water loss, transdermal electrical resistance or caffeine penetration levels are often chosen techniques. New results demonstrate that

Strategies to Reduce Contact Allergy to Fragrances

The author discusses current animal-based testing and proposes a strategy based on maximum permitted levels of certain fragrance ingredients in cosmetics as ways to reduce contact allergy to fragrances in cosmetic products.