Research from the Albert Einstein College of Medicine has revealed that the hypothalamus has a role in controlling aging—via microRNA (miRNA).
A new paper published in Nature describes how mouse models served as a basis to study aging. According to the article abstract, mice having fewer or damaged hypothalamic stem/progenitor cells displayed accelerated aging-like physiological changes and/or a shortened lifespan. Conversely, slowed aging and an extended lifespan were achieved in mid-aged mice implanted with healthy hypothalamic stem/progenitor cells.
The researchers found that hypothalamic stem/progenitor cells contribute greatly to exosomal miRNAs in the cerebrospinal fluid. And while miRNAs declined during aging, treatment with healthy hypothalamic stem/progenitor cell-secreted exosomes slowed aging.
This study connects with recent work from the cosmetic world on miRNAs for skin benefits. Indeed, it aligns with a recent flurry of epigenetic research for anti-aging applications. It's certainly an area for the industry to watch, and one with great implications on the nearby horizon.