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Acetyl Zingerone Prevents Dark CPD Formation in Skin

Contact Author Rachel Grabenhofer
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Research continues to emerge on the damage that occurs in skin post-UV exposure; i.e., after exposure is ceased and even in the dark. DNA is damaged via the formation of 'dark cyclobutane pyrimidine dimers' (CPDs)—but cosmetic ingredient innovators are stepping up with materials to counter this CPD formation.

3-(4-Hydroxy, 3-methoxybenzyl)-pentane-2,4-dione (INCI: Acetyl Zingerone; AZ) is a recent example. In a paper published in the International Journal of Cosmetic Science, a team of researchers from Sytheon, the Moffitt Cancer Center and Yale University found this ingredient protected against ongoing DNA damage in melanocytes after UV exposure ended.

See related: Chrysanthemum Blend Inhibits UVA Damage Post Exposure 

Incubation with AZ before irradiation decreased the intracellular levels of UVA-induced ROS formation in keratinocytes. Furthermore, compared with α-tocopherol, the molecular structure of this material provided significantly better photostability and efficacy to neutralize free radicals, quench singlet oxygen and scavenge peroxynitrite.

Supplied commercially as Synoxyl AZ, the ingredient is said to hold strong potential for extending the photoprotection afforded by traditional sunscreens and daily skin care products above and beyond where exposure ends.

For more information, contact Sytheon.

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