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Patent Picks: Biofilms, Solid Mouthwash and CBD in Oral Care

Contact Author Rachel Grabenhofer
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Following its launch of Colgate Zero in 2020, offering oral care without artificial flavors, sweeteners, preservatives and colors, the company describes innovations related to biofilms, a solid mouthwash and CBD in recent disclosures, provided here in brief.

See related: Oral Care Refresh; Intersecting Function with Beauty and Innovation

Methods of Modifying Biofilms

WIPO Patent Application WO/2021/092613
Publication date: May 14, 2021
A
ssignees: Colgate-Palmolive Company and Regents of the University of Michigan

Abstract: According to this disclosure, despite advances in oral care therapeutics, there remains a need for new approaches to address the problems of oral biofilms. Challenges include reducing the ability of biofilms to attach, or remain attached, to an oral cavity surface; compromising the structural integrity of biofilms; and/or making the biofilms more susceptible to penetration by antimicrobial agents.

Embodiments of the present invention are designed to address these and other needs. For example, one embodiment provides methods for modifying or manipulating the surface topography or thickness of an oral biofilm by administering a composition comprising an effective amount of a basic amino acid or a divalent metal ion source to the oral cavity. The basic amino acid is selected from arginine, lysine and histidine; and the divalent metal ion source is selected from a zinc ion source (e.g., zinc citrate, zinc oxide, zinc lactate, zinc chloride or zinc phosphate); and a stannous ion source (e.g., stannous fluoride or stannous chloride).

Solid Compositions for Teeth Whitening and Antimicrobial Effects

European Patent Application EP3817707
Publication date: May 12, 2021
Assignee: Colgate-Palmolive Co. (U.S.)

Abstract: Described here is a solid composition for oral care comprising at least one whitening agent chosen from: chloride isocyanurate and metal salts of hypochlorite; at least one carbonate base; and optionally at least one effervescent acid. Further disclosed is a kit comprising the solid composition and an aqueous liquid composition, as well as methods of whitening teeth and/or producing antibacterial effects in the oral cavity, that are mixed until the solid composition disintegrates to create a mouthwash comprising hypochlorite, and contacting teeth with the mouthwash comprising hypochlorite.

From the archives: Addressing Tooth Sensitivity and Dental Erosion

Oral Care Comprising Cannabinoids

WIPO Patent Application WO/2021/071867
Publication date: April 15, 2021
Assignee: Colgate Palmolive Co. (U.S.)

Abstract: As this patent explains, unchecked bacterial growth in the oral cavity can lead to a number of adverse conditions such as gingivitis, an inflammation of the gums. It is ordinarily caused by bacterial accumulations on the surface of the teeth, which may be in the form of plaque. Gingivitis results in a number of unpleasant symptoms including inflamed gums that are painful or sensitive, halitosis and bleeding from the gums while brushing or flossing.

Other common disorders of the mouth include abscesses and cold sores, which also involve inflammation and are painful to those afflicted. As such, there is a need for oral care compositions with antibacterial efficacy that are also palatable and desirable for a user. According to these inventors, it is believed that oral care compositions including cannabinoids such as CBD provide antibacterial and anti-inflammatory properties.

This invention relates to oral care compositions comprising a cannabinoid source; a thickening system comprising xanthan gum and carrageenan; and an orally acceptable carrier. It also relates to oral care compositions comprising a cannabinoid source, a surfactant system comprising an acyl glutamate, a non-silica abrasive (e.g., calcium carbonate or charcoal) and an orally acceptable carrier.

WIPO Patent Application WO/2021/072422
Publication date: April 15, 2021
Assignee: Colgate Palmolive Co. (U.S.)

Abstract: In relation to the above patent, this invention relates to oral care compositions comprising a cannabinoid and one one more source(s) of zinc ions and/or stannous ions. The zinc ions may be selected from: zinc oxide, zinc citrate, zinc lactate, zinc phosphate and combinations thereof; the source of stannous ions comprises stannous fluoride.

According to this patent, the inventors believe that oral care compositions with cannabinoids such as cannabidiol, in combination with one or more sources of zinc ion and/or one or more sources of stannous ion, provide antibacterial and anti-inflammatory properties. Moreover, the inventors have surprisingly demonstrated that cannabidiol in combination with one or more zinc ion source(s) and/or a stannous ion source, can enhance the efficacy of stannous and zinc in suppressing certain bacterial cellular metabolism.

WIPO Patent Application WO/2021/072423
Publication date: April 15, 2021
Assignee: Colgate Palmolive Co. (U.S.)

Abstract: Lastly, this disclosure relates to oral care compositions comprising amino acids and a cannabinoid. The inventors report they have surprisingly demonstrated that cannabidiol in combination with a basic amino acid, e.g., arginine, can enhance the efficacy of arginine in suppressing bacterial cellular metabolism.

Patents accessed on May 17, 2021.

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