Could Senescent Skin Cells Age the Entire Body?

Jan 19th, 2022

UV-induced skin aging can affect the brain, decreasing hippocampal neurogenesis, for example.

UV-induced skin aging can affect the brain, decreasing hippocampal neurogenesis, for example.

Researchers from the University of Coimbra, Portugual, have published an opinion in Trends in Molecular Medicine proposing senescent skin cells could cause aging throughout the body.

As is well-known, aged skin shows structural, cellular and molecular changes and the accumulation of senescent cells. These cells can induce or accelerate age-related dysfunction in nearby cells.

See related: Disrupted Splicing in Cellular Senescence Presents Novel Anti-aging Target

According to the authors, aging and cellular senescence phenotypes in the skin correlate with immunosenescence, longevity and/or cardiovascular disease risk. Furthermore, UV-induced skin aging can affect the brain, decreasing hippocampal neurogenesis, for example.

Topical senolytics such as dasatinib and fisetin also are discussed to selectively eliminate senescent cells for anti-aging effects.

See archived: Testing Tactics in Skin; Targeting Senescent Cells for Anti-aging

Color Cosmetics: Balancing Naturality, Sensoriality and Performance

Color Cosmetics: Balancing Naturality, Sensoriality and Performance

Natural makeup is on the rise, especially in Europe, with other regions following. While natural ingredients are available, the balance between naturalness, sensoriality and performance is a challenge that lipid chemistry can meet successfully.

La Mer: New Findings on Skin Inflammation

Lead scientist of luxury brand reveals recent findings that may shape the future of inflammation skin care products.

happy platinum blonde woman shiny skin holding product tube near and dear to her face

Editor's Note: Radiant Beauty Innovation

Skin radiance goes by many names, including luminosity, glow, brightness and more recently, pearl skin. In the end, though, it comes back to the desired characteristics of healthy, unflawed and youthful skin. This is the main focus of our latest issue.

'All participants had a physical count of their hair by a blinded clinician at baseline, 12 and 24 weeks, and the results were also confirmed with blinded photo-grading,' says Jay Small, a trichologist and cofounder of Arey. 'There was a statistical significance between active and placebo groups at both the 12 and 24 week mark.'

Arey's 'The System' Cuts Gray Hair Growth and Boosts Repigmentation by Combatting Canities: New Clinicals

"Vitamin and mineral deficiency, along with oxidative stress from factors like sun and chemical exposure, contribute to hair losing pigment and turning gray," says Jay Small, a trichologist and cofounder of Arey.

woman smart sassy holding jar of skin cream - hair pulled back - shoulders and up AdobeStock_595997467

Western University Scientists Uncover Protein with Next-level DNA Damage Repair Potential

The protein could be introduced into any organism to increase its cellular DNA repair efficiency. Mindy Goldstein, Ph.D., weighs in: "This is the first direct proof of a DNA repair enzyme from [D. radiodurans] that works through a unique mechanism."

Black woman smiling holding cucumber slices over her eyes hair up in towel

Editor's Note: Pursuit of Skin Health and Happiness

Concerns over skin health are on the rise. Here, we present solutions for healthy skin and scalp, including: oily/acneic and compromised skin care, a natural microbiome-focused deodorant, anti-hair loss scalp care, wellness beauty, dermocosmetics, etc.

Woman In Blue Light High Tech Facial Concept Recombinant Protein Story Adobe Stock 837834848

The Rise of Recombinant Proteins in Beauty - and Making them Scalable

Considering the momentum recombinant proteins are gaining in beauty, here C&T takes closer look at what they are, how they're used, market demand, future directions and their production, with Mindy Goldstein, Ph.D., and Johnny Cordiner, CEO, Phenotypeca.

Per the latest research, Apiscalp reduces scalp itching by 80% among those test subjects with textured hair.

New Research Shows Croda's Apiscalp Delivers Scalp Care for Textured Hair

Per the latest research, Apiscalp reduces scalp itching by 80% among those test subjects with textured hair.

Woman Hidden Plants Thoughtful Happy Adobe Stock 142377452

Editor's Note: Catching 'Green Fever'

This issue presents green/sustainable ideas and emphasizes the urgency of reducing negative environmental impacts. The industry has been catching "green fever" for a while now and every bit counts. Hopefully it adds up enough in time to make a difference.

“Ocean beauty trends, focusing on sustainably sourced marine ingredients, are also emerging. These changes signify a shift toward environmental responsibility.'

Expert Opinions on Responsible Beauty: Ocean Sourced, Fermented, Planet Positive, AI Enabled and Consciously Cultivated

“Toxin-free,” zero impact, fair trade, biodegradable, etc., are all facets of the responsible beauty movement. This month, we asked several industry experts to weigh in about the meaning of responsible beauty and its current and future market directions.

Woman Rainforest Green Adobe Stock 89226842

Climate Change, Beauty’s Influence and a Sustainable Path Forward

This article describes drivers of climate change and how our industry can mitigate them. It also explores the impact of climate change on naturals, novel farming/biotech solutions and choices formulators can make to support sustainability.