The frequency of use of cosmetics and personal care products, urinary concentrations of benzophenones and parabens, and potential risk for endometriosis were associated in work published in Environmental Research.
Evaluations were made in 124 women (35 cases; 89 controls). Endometriosis was confirmed (cases) or ruled out (controls) by laparoscopy. Urinary concentrations of benzophenone-1 and 3; 4-hydroxibenzophenone; and methyl-, ethyl-, propyl- and butylparaben were quantified, in addition to biomarkers of oxidative stress. Information also was gathered on the subjects' frequency of use of cosmetics and personal care products. Associations were explored in logistic and linear multivariable regression analyses.
See related: CIR Conclusion, Parabens are Safe
Results suggested the frequency of use of certain personal care products was significantly associated with urinary concentrations of benzophenones and parabens. After adjustment for potential confounders, the risk for endometriosis also appeared to increase in women with repect to methylparaben; benzophenone-1; benzophenone-3; and both benzophenones combined. Oxidative stress results did not affect the associations observed.
It is important to note the authors suggest further studies are warranted to corroborate these findings. This is especially true considering bad press ingredients have received in the past based on flawed study designs or misleading conclusions.
Furthermore, the independent Cosmetic Ingredient Review (CIR) board has previously established the safety of both parabens and benzophenones-1 and -3 under topical application, at appropriate cosmetic concentrations and during conditions of intended product use.