Skin Aging at the Functional Proteomics Level: Elastin as a Marker

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Papers published over the past two decades describing how changes in elastin are associated with skin photoaging are both puzzling and varying. Some point toward the activation of proteolytic enzymes that cleave elastin in a randomized manner, leading to decreasing structural integrity and inelasticity; others point to an accumulation of the secreted soluble precursor protein tropoelastin, in a condition termed solar elastosis. Though there is consensus on the importance of elastin in skin health and appearance, no systematic method has elucidated how the clinical manifestations of elastin in the dermal layer are correlated to its structure-function attributes.

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