Many restrictive norms are applied to cosmetic formulations all over the world, prohibiting or limiting the use of certain ingredients. For example, general good manufacturing practices and guidelines indicate the best procedures for safe manufacturing and filling. These limitations are usually based on safety considerations, especially the allergenic or irritant potential of ingredients and their combinations. Moreover, potential side effects, the toxicological profile of the formula, the sensitivity of the skin application site and the consumer’s age are carefully considered. In addition, ingredients from animal sources, the purity profiles of raw materials and their blends, the frequency of use and duration on the skin, and impurities content are taken into account to establish a product's compliance to the principles of consumer safety.