[updated; poll results] How Do You Ensure the Reproducibility of Lab-scale Batches?

multiple beakers duplicates lined up with blue liquid in them
Image by JoseFelix at Adobe Stock

Last week, we noted that according a report in BioTechniques, there is a "replication crisis" that has gained traction in the scientific community over the past 10+ years. "Basic researchers have shown the reproducibility of key data from the lab is low and there is a clear need to improve lab protocol and technique," the abstract states.

In consideration, we asked: How do you ensure the reproducibility of lab-scale batches? See the results below.

Update: In connection with this scrutiny, the scientific community fired back, blaming the "publish or perish" culture for the reproducbility crisis, Technology Networks reported. In a survey of more than 1,600 researchers in 80+ countries, more than 62% of participants attributed irreproducibility in science to the “publish or perish” culture.

Per the source, "the pressure to 'publish or perish' reflects the unfortunate reality that, oftentimes, researchers must consistently publish in prestigious journals to secure long-term career prospects. This creates a perpetual cycle of fear and pressure that is unconducive to a flourishing research environment."

Poll Results

  • Strictly following SOPs and protocols 60%
  • Meticulous weighing and measuring techniques 24%
  • Using standardized equipment settings 16%
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