
Exosomes are rapidly gaining attention in the wellness industry for their powerful ability to support cellular repair and rejuvenation. These microscopic vessels, produced by stem cells, fibroblasts and macrophages, transport crucial peptides, growth factors and cytokines that help guide the repair and regeneration of tissues in the body. As the wellness community explores the potential of exosomes, it’s important to understand how they work, their role in the body’s healing process and why they are becoming such a sought-after tool in treatments aimed at combating aging and promoting skin health. Dr. Ben Johnson, Osmosis founder, CEO and an expert in the field, explains how exosomes are revolutionizing wellness therapies and what sets them apart from traditional treatments. This work has led to the creation of the Osmosis StemFactor and StemFactor MD Growth Factor serum, and the highly anticipated launch of a new professional treatment—Osmosis Exosome Infusions™—launching this year.
Skin Inc. (SI): For those unfamiliar, could you briefly explain what exosomes are and their function in the human body?
Ben Johnson, MD (BJ): Exosomes are small protective vessels produced by our stem cells, fibroblasts and macrophages. These cells create exosomes to carry peptides, growth factors and cytokines that guide the repair and development of the body's organs. The effectiveness of an exosome depends largely on the signaling peptides it contains. Although "stem cell-derived growth factor media" has been used for over 20 years, the focus on the exosomes within this media is only now gaining widespread attention.
Some people go to extremes, like injecting stem cells into their faces for rejuvenation. However, stem cells are not always active—many remain dormant. To boost repair activity, using exosomes daily (or at least monthly in larger quantities) is more effective. Treatments like acid/alkaline peels and lasers stimulate collagen, but they do so by repairing the damage they just caused. In contrast, Exosome Infusions™ activate collagen without harming the skin, allowing it to focus on repairing sun damage rather than the trauma from recent treatments. It's also safe for all skin types, from the most compromised to normal, aging skin.
SI: Are there any misconceptions about exosomes or their use in wellness that you’d like to clarify?
BJ: Yes! First, it's important to note that exosomes are not regulated by the FDA because they aren’t human biologic material. While we use human stem cells and fibroblasts to produce the growth factors, the cells themselves are not part of the exosome-based growth media in each bottle. Second, there's a significant difference in both the number of exosomes per milliliter and the variety of growth factors that each company includes in their products. Don't get caught up in the debate over where the stem cells come from or whether they’re delivered frozen or at room temperature—these are just marketing tactics. Exosomes are naturally produced by your body and are stable at temperatures up to 98°F.
To properly assess exosomes, ask what variety of growth factors, peptides and cytokines are proven to be in the growth media. This is an easy evaluation, yet many companies don't share their raw data. Additionally, inquire about the number of exosomes in the product. This is another straightforward test. Osmosis believes many companies avoid sharing this data because their numbers don’t compare to ours. We’ve proven in lab analysis that our growth media contains over 600 different growth factors/peptides, the highest count in the world, and we have 47 times more exosomes than our nearest competitor—a staggering 3.5 trillion exosomes per bottle of StemfactorMD (even more with our Exosome Infusion™ Treatment). This makes our products a powerful tool for estheticians, medical professionals and their clients.
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