Trifluoroacetyl-Tripeptide-2 to Target Senescence for Anti-aging Benefits

Skin aging is characterized by progressive changes in the regulation of cellular processes and miscommunication between cells and their immediate environment, the extracellular matrix (ECM). These malfunctions, which may result from physiological and/or environmental events, are most notably characterized by the increased activities of metalloproteinases (MMPs) and the reduced synthesis of their endogenous inhibitors, i.e., tissue MMP inhibitors (TIMPs),^1–5 as well as the reduced biosynthesis of major ECM proteins.⁶ As a result, the extracellular matrix is no longer renewed and the skin shows the effects of aging.