Naolys has tapped into the natural power of calendula to develop an anti-aging solution to revitalize and regenerate skin "deep down." According to the company, InnerLift Calendula (INCI: Calendula Officinalis Callus Extract) stimulates inner skin structures to proactively fortify the skin's foundation at both dermal and epidermal levels.
Calendula’s botanical DNA is rich in beneficial compounds such as flavonoids, carotenoids and phenolic acids, providing the plant cells with anti-inflammatory, soothing and regenerative properties. Applied in skin care, these entities are said to boost skin’s resilience and ensure a well-nurtured cellular framework. Thus, the ingredient is positioned as an "investment for ageless vitality and a radiant complexion."
InnerLift Calendula: Multifunctional Mechanisms of Action
InnerLift Calendula reportedly supports holistic regeneration effects by working in synergy with the body’s natural mechanisms to restore the skin’s health and vitality. It achieves this through:
- A holistic approach: intervening in epidermal differentiation, regulating inflammation and restoring skin lipids. This establishes harmony between external and internal factors for fully optimized skin, per the company.
- Intelligent cellular stimulation: specifically targeting oxidation-sensitive proteins and senescent cells, stimulating the production of essential components such as elastin, glycosaminoglycans (GAGs), collagen and ceramides.
- Enhanced protection and barrier function: actively protecting against internal and external threats, minimizing water loss, promoting water retention and reinforcing the skin’s barrier function, creating an active defense.
- A preserved extracellular matrix: caring for the extracellular matrix, fostering deep cell regeneration, contributing to skin resilience, elasticity and firmness to preserve the skin’s structural integrity.
Clinical Efficacy of InnerLift Calendula
Clinical studies of the active were carried out for 28 days in 20 women ages 40 to 60 years old. Assessments were made by the Quantirides system, to assess skin micro and macro topography, and corneometry, to determine hydration. Subjects applied an emulsion including 0.5% InnerLift Calendula (20% cells) twice daily. Results revealed an increase in skin moisture after 2 hr and a decrease in wrinkles after 28 days of application, versus the control.
Furthermore, the product imparted:
- a soothing effect, as demonstrated by a study of inflammation mediators IL-6, IL-1 alpha, PGE2;
- anti-aging, firming and reconstructive benefits, as shown by the synthesis of collagen, elastin and glycosaminoglycans;
- regenerating efficacy, assessed by the study of cell proliferation with KI-67 reconstructive effect;
- corneocyte cohesion, shown by the study of loricrin, involucrin and ceramides; and
- anti-ageing effects, through studies of cell senescence, β-galactosidase assay.
Technical Specs, Marketing Claims of InnerLift Calendula
According to the company, InnerLift Calendula supports skin care claims, including the following.
- Combatting oxidized proteins/antioxidant effects/cellular preservation
- Skin cohesion/maintaining optimal skin barrier structure
- Deep cell regeneration
- Remodeling the extracellular matrix/the skin's ability to adapt to aging
- Anti-inflammation, calming redness, irritation and discomfort
- Lowering/reducing the number of senescent cells in skin
The product is available in two forms: liquids — soluble cells (20%) in glycerin or sunflower oil (80%); and powder — dispersible cells (100%), in concentrations starting at 0.5%. It is reportedly suitable for all types of formulations.
