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Iontophoresis is a well-known, noninvasive method that uses a small electric charge to deliver chemicals through the skin. However, according to Gregory Schultz, PhD, and Daniel Gibson, a professor and doctoral candidate, respectively, at the University of Florida, this method of delivery can have its drawbacks. Together with co-inventor, Sonal Sanjeev Tuli, MD, the team developed a method to iontophorese macromolecules into tissue such as the skin without causing damage; however, initial research focused on the eye. Research on perfluorocarbons (PFCs) began before World War II but it was the 1942 Manhattan Project in the United States to develop the atomic bomb that led to methods of producing PFCs other than reacting fluorine with hydrocarbon. As a result, PFCs have been adapted for a number of industries including traumatic brain injury, sickle cell crisis pain, trauma, wound care, decompression sickness, acute respiratory distress syndrome, stroke, myocardial infarction, surgery, diabetes and cosmetics.