The PremiseAccording to inventors at Sungkwang Medical Foundation, Seoul, and the College of Medicine Pochon CHA University, Pocheon-si, Korea, Theobroma cacao (cacao) beans contain large amounts of polyphenols; specifically, flavan-3-ol like epicatechin, procyanidin, catechin polymer, etc. These are stored in the pigment cells of embryonic seed leaves at levels of approx. 10% cacao bean weight.Furthermore, a limtless number of studies has shown that such antioxidants can improve skin conditions. Under these circumstances, the present inventors aimed to develop a plant-derived material to prevent skin aging, especially photoaging.
Composition for preventing, improving or treating photoaged skin comprising the cacao metabolite DHPV
US Pat 20190021976A1
Publication date: Jan. 24, 2019
Assigee: Assignee: Sungkwang Medical Foundation and the College of Medicine Pochon CHA University
This patent application discloses a photoaging inhibitor, more specifically a pharmaceutical, food or cosmetic composition, for preventing, improving or treating photoaged skin. It comprises 5-(3′,4′-dihydroxyphenyl)-R-valerolactone (DHPV), a metabolite of cacao.
According to the inventors, DHPV is excellent in respect to biosafety and it effectively regulates the expression of proteins related to skin aging epigenetically, even at concentrations as low as 1 nM.
Patent application accessed on Feb. 13, 2019.