Patent Picks—Autophagy for Skin, Hair Color; Luster Pigment; Depigmenting Compounds and More in Color and Coloration

Patent Picks are compiled by the editors from publicly available sources. This edition features inventions that relate to color cosmetics and skin coloration, including autophagy to regulate skin and hair color, layered and luster pigments for cosmetics, mineral powder with high dispersion, approaches for depigmenting and evening out skin tone, and more.

Autophagic factors to control skin and hair color
U.S. Patent 8927517
Publication date: Jan. 6, 2015
Assignee: Kao Corp.

This invention relates to the use of autophagic activity for regulating the amount of melanin in a keratinocyte, in turn controlling skin or hair color. Researchers confirmed that autophagic activity is associated with the amount of melanin in keratinocytes, and that there is a high correlation between autophagic activity and skin color. In relation, materials of interest for their capability to control skin or hair color can be evaluated or selected using autophagic activity as an indicator, for the further development of skin lightening agents, skin-tanning agents, hair coloring or bleaching agents, or hair dyes.

Flaky particles and luster pigment for cosmetics
U.S. Patent 8926746
Publication date: Jan. 6, 2015
Assignee: Nippon Sheet Glass Co., Ltd.

This patent relates to flaky particles and a luster pigment, as well as a cosmetic, coating composition, resin composition and ink composition containing them. Said luster pigment contains flaky particles and at least one selected from a metallic layer and a metallic oxide layer that are formed on at least a part of the surface of each of the flaky particles. The luster pigment has a particle size distribution in which a value of D90/D10 is at least 2.0 but not more than 3; a value of D10 is at least 4.7 μm but not more than 25 μm; and a maximum particle diameter is 90 μm or less (where D10 is defined as a particle diameter at which a cumulative volume of particles reaches 10% when counted from the smaller side, and D90 is defined as a particle diameter at which a cumulative volume of particles reaches 90% when counted from the smaller side).

Iron oxide-coated layered silicate pigment for cosmetics
U.S. Patent Application 20150005393
Publication date: Jan. 1, 2015
Inventors: M. Abiko, R. Seike and T. Hoshino

This invention relates to an iron oxide-coated layered silicate pigment that has no interference color, strongly exhibits the color inherent in iron oxide, and is excellent in gloss. The pigment comprises a layered-silicate plate particle as the base and an iron oxide coated on the plate particle, wherein the iron oxide does not coat the surface portion of the plate particle or the iron oxide is localized on the edge portion rather than the surface portion of the plate particle. At least one iron oxide is used, preferably chosen from black iron oxide (Fe3O4) and red iron oxide (Fe2O3). A mica-group layered silicate can also be used.

Mineral material powder with high dispersion ability
U.S. Patent Application 20150000564
Publication date: Jan. 1, 2015
Inventors: P. Blanchard, J.-P. Elgoyhen, B. Karth, H. Müller, J. Spehn, M. Brunner, P. Gonnon and M. Tinkl

According to this patent, today, costly resins in products are often replaced with less expensive fillers and/or pigment materials in order to reduce costs, while at the same time trying to improve mechanical and/or optical properties of the unfilled material. In relation, disclosed herein is a mineral matter powder prepared by a wet process without acrylic or other grinding aid additives and its use after an optional hydrophobic treatment. This material showed superior dispersing properties and is suggested for use as a mineral filler for coatings, food, cosmetics, pharmaceuticals and more. 

1-Aryl-2-aryloxyethanes for novel anti-aging and depigmenting properties
U.S. Patent Application 20150004110
Publication date: Jan. 1, 2015
Assignee: Diverchim

The present patent describes cosmetic compositions that contain 1-aryl-2-aryloxyethanes, which present useful biological properties for anti-aging, depigmenting, anti-inflammatory and/or wound-healing benefits. One example provided herein describes a preparation to reinforce the dermis, and increase the proliferation of dermal fibroblasts and production of collagen. It also showed anti-tyrosinase and anti-melanogenesis activity by inhibiting the expression of the matrix metallopeptidase gene MMP9 and of the “heat shock protein beta-1” HSPB1. 

Danielone and derivatives to even skin tone
U.S. Patent Application 20150004108
Publication date: Jan. 1, 2015
Inventors: R. Campache, P. Geotti-Bianchini and H. Ziegler

The present invention relates to a novel composition comprising danielone and derivatives thereof, as well as to the use of such compositions in skin lightening and to even out skin color irregularities; for example, reducing melanin formation.

Highly pure crystalline polymorphs of acetyl-glycine-beta-alanine for skin lightening
U.S. Patent 8927767
Publication date: Jan. 6, 2015
Assignee: Corum Inc.

Disclosed in this patent is a method of synthesizing acetyl-glycine-beta-alanine and its use for skin lightening. Previously, crude acetyl-glycine-beta-alanine was obtained with an HPLC purity of 95%. However, for active ingredients used in cosmetic and pharmaceutical industries, an HPLC purity of more than 99% is required. The polymorphs of acetyl-glycine-beta-alanine described here provide the desired purity and exhibit excellent storage stability. Further, ex vivo tests in a human epidermis model showed that 2% of acetyl-glycine-beta-alanine exhibited excellent whitening efficacy (existing melanin level: -30%) in nine days.

Topical photoactive compound and laser therapy to improve skin tone
U.S. Patent Application 20150005692
Publication date: Jan. 1, 2015
Inventor: D. Barolet

This invention provides a method of treating skin based on photodynamic therapy used in conjunction with a topical photoreactive substance to improve skin tone and appearance. It involves applying the treatment composition; irradiating it with a first pulse having a power density above an activation threshold power density and emitting the pulse for a duration of from about 1 femtosecond to 1 hour; and separating the first pulse from a second pulse by about 1 microsecond to about 10 seconds. The application of said light-sensitizing solution to skin marred by scaly lesions, skin blotchiness and enlarged pores, followed by the delivery of a light treatment appears to enhance cosmetic skin appearance by improving skin tone, texture and pore size.

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