Patent Picks—Etyllinoleate, Dibenzoyl Peroxide, Pentane-1,5-Diol, Microcapsules and More for Treating Acne

Device and method for controlled delivery of active substance into the skin 
US Patent 7979117
Publication Date: July 12, 2011
Assignee: Power Paper Ltd.

This patent discloses an apparatus for the dermal delivery of an active substance, and the apparatus is based on a flexible, wearable patch conformable to the contour of a skin surface.

The apparatus is comprised of: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.

The flexible dermal patch can be utilized for treatment of a disorder selected from the group consisting of: aging skin, dry skin, sun damaged skin, wrinkles, age spots, various hyperpigmented spots, melasma, puffy eyes, acne, redness of the skin, telangiectasia, cellulite, obesity, dermatitis, contact dermatitis, atopic dermatitis, seborrheic dermatitis, nummular dermatitis, chronic dermatitis of the hands and feet, generalized exfoliative dermatitis, stasis dermatitis, bacterial infections of the skin, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, cutaneous abscesses, necrotizing subcutaneous infections, Staphylococcal scalded skin syndrome, folliculitis, furuncles, hidradenitis suppurativa, carbuncles, paronychial infections, erythrasma, viral skin infection, herpes, disorders of the hair follicles and sebaceous glands, rosacea, perioral dermatitis, hypertrichosis, alopecia, pseudofolliculitis barbae, keratinous cyst, scaling popular diseases, psoriasis, pityriasis rosea, lichen planus, pityriasis, rubra pilaris, pigmentation disorders, hypopigmentation, hyperpigmentation, warts, scars, benign tumours, moles, dysplastic nevi, skin tags, lipomas, angiomas, pyogenic granuloma, seborrheic keratoses, dermatofibroma, keratoacanthoma, keloid, malignant tumors, actinic keratosis, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, Paget's disease of the nipples, Kaposi's sarcoma, a fungal infection, pain, inflammation and a combination thereof.

Low toxicity topical active agent delivery system
WIPO Patent Application WO/2011/081672
Publication Date: July 7, 2011
Assignee: JE Kulesza

An active agent delivery composition is provided that allows topical delivery of active agents including vitamin A and its derivatives. A polyhalogenic vehicle such as methoxyonafluorobutane or ethoxyonafluorobutane serves as a coupler for an active agent and a silicone carrier so as to allow solubilization of active agents not normally miscible in silicones and providing a moisture maintaining composition. Lipophilic skin care active agents such as retinoids are generally applied topically to reduce the appearance of aging, for other cosmetic purposes, or to treat a skin condition such as acne.

Core stabilized microcapsules, method of their preparation and uses thereof
WIPO Patent Application WO/2011/080741
Publication Date: July 7, 2011
Assignee: Sol-Gel Tehnoloties Ltd., O Toledano, H Bar-Simantov, H Sertchook, S Fireman-Shoresh and D Marco-Dagan

The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

The present invention provides a process for preparing microcapsules having a core encapsulated within a metal oxide shell, said process comprising: preparing an o/w emulsion by emulsifying an oily phase comprising at least one active agent and at least one phase changing material in an aqueous phase, wherein at least one of said oily phase and aqueous phase comprise a sol-gel precursor; subjecting said emulsion to microcapsule forming conditions; thereby obtaining said microcapsules.

In a further aspect, the invention provides a method for treating a surface condition in a subject in need thereof, comprising topically administering to said subject a composition of the invention. The invention further provides a composition comprising microcapsules of the invention, for the treatment of a disease, disorder or condition selected from acne, infection, inflammation, puritis, psoriasis, seborrhea, contact dermatitis, rosacea and a combination thereof.

Dibenzoyl peroxide derivatives, preparation method thereof and cosmetic or dermatological compositions containing same
WIPO Patent Application WO/2011/080469
Publication Date: July 7, 2011
Assignee: Galderma Research & Development, N Rodeville, J PASCAL,  and C Biouix-Peter 

The invention relates to the use of compounds with a general formula. The invention also relates to the preparation method thereof and to the cosmetic or dermatological use of same. The compounds of the invention act as bactericidal agents. Consequently, said compounds can be used in the treatment of conditions associated with the presence of bacteria, specifically P. acnes.

Composition based on etyllinoleate and triethylcitrate for the treatment of seborrhea and acne
European Patent EP1455899
Publication Date: July 6, 2011
Assignee: General Topics S.R.L.

The object of the invention is to provide a new product characterized by being highly efficacious with excellent cutaneous tolerability, in particular in the treatment of seborrhoea, acne and acne rosacea. The object is achieved, according to the invention, with a composition containing an active ingredient mixture including the ethyl ester of linoleic acid (ethyllinoleate) and triethylester of citric acid (triethylcitrate). This composition results as being able, among other things, to inhibit the activity of specific enzymes, such as 5-alpha reductase, lipase and esterase, enabling a control of the seborrhoea and in general the evolution of the acneic and rosacea picture.

Method for inhibiting the growth of antibiotic resistant of bacteria by using pentane-1,5-diol
US Patent 7973080
Publication Date: July 5, 2011
Assignee: Ambria Dermatology AB

The present invention is based on the insight that pentane-1,5-diol is effective against multiple-resistant bacteria. The inventors have found that compositions comprising 15% w/w or more of pentane-1,5-diol and a suitable carrier that lacks bacteriostatic effect or the bacteriostatic effect of which is less than 5% w/w of the bacteriostatic effect of pentane-1,5-diol in respect of a particular microorganism provide efficient bacteriostasis against multiple-resistant bacteria. This is entirely unexpected even in view of the known moderate antibacterial effect of pentane-1,5-diol and similar diols. In addition, there is reason to believe that the bacteriostatic effect of the invention is shared by other low-molecular weight aliphatic diols, such as propane-1,2-diol, propane-1,3-diol, butane-1,2-diol, butane-1,3-diol, butane-1,4-diol, butane-2,3-diol, 2-methylpropane-1,2-diol, 2-methylpropane-1,3-diol, 2-hydroxymethyl-1-propanol, pentane-1,2-diol, pentane-2,3-diol, 2-hydroxymethyl-1-butanol, 2-methylbutane-1,2-diol, 3-methylbutane-1,2-diol, 2-methylbutane-1,3-diol, 3-methylbutane-1,3-diol, 2-methylpentane-1,4-diol, hexane-1,2-diol, hexane-1,6-diol, 2-methylpentane-1,5-diol, 3-methylpentane-1,5-diol.

Due to the low acute and long-term toxicity of pentane-1,5-diol, the bacteriostatic composition of the invention may be used as a pharmaceutical for topical administration but also as a disinfectant which, in contrast to other efficient disinfectants, poses no health risk to persons using it. An additional advantage of the composition of the invention is that it does not give rise to resistant strains of bacteria. The composition of the invention may take the form of a liquid, semi-liquid or solid disinfectant preparation, a bacteriostatic solution, lotion, cream, soap, shampoo, ointment, paste, wet towel, hygiene dish, patch, diaper or similar personal hygiene protection device. In a preferred embodiment the composition of the invention is combined with antibiotic, antiviral agent, antiseptic, agent for treatment of acne and with other agents used in the treatment of infectious diseases of the skin and the mucous membranes.

Growth factor-mimicking peptides and uses thereof
US Patent Application 20110160131
Publication Date: June 30, 2011
Assignee: Caregen Co., Ltd.

The present invention relates to a growth factor-mimicking peptide with an activity of the growth factor, and a composition and a method for improving skin conditions or for treating a wound using the same. The growth factor-mimicking peptides of this invention have identical functions or actions to natural-occurring human growth factor, and much better stability and skin penetration potency than natural-occurring growth factor. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding growth factor activities. In addition, excellent activity and stability of the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

Skin pore minimizers and skin elasticity improvers
US Patent 7968607
Publication Date: June 28, 2011
Assignee: Kao Corp.

This invention relates to skin pore tighteners each of which comprises, as an active ingredient, a compound represented by the following formula: R1—OG, wherein R1 represents an alkyl or alkenyl group with 8 to 32 carbon atoms and OG represents a residual group obtained by removing a hydrogen atom from a hydroxyl group of a polyhydric alcohol, monosaccharide or oligosaccharide, at least one hydroxyl group of which has been sulfated or phosphatized, or a salt thereof.

The skin elasticity improvers comprise, as an active ingredient, a glyceryl ether derivative represented by the following formula: wherein R1 represents the same group as defined above, and X1 and X2 each independently represents a hydrogen atom, —SO3OH or —PO(OH)2 with the proviso that X1 and X2 are not hydrogen atoms at the same time, or a salt thereof.

Iodide salts of dimethylaminoethanol fatty acid esters with bacteriostatic, mycostatic, yeaststatic and/or microbicide activity for use in cleansing or purifying formulations
European Patent EP1892236
Publication Date: June 22, 2011
Assignee: Scharper S.p.A.

The applicant has now prepared new salts of dimethylaminoethanol fatty acid esters of general formula in which R is a C6-C16 linear or branched alkyl radical, X- = l-, and which, as well as being biocompatible, has bacteriostatic, mycostatic, yeaststatic and/or microbicide activity. In addition to have said properties, these salts are sufficiently water soluble with surfactant properties so that said aqueous solutions, which contain them, form a substantial amount of foam. These salts can hence be advantageously used in purifying or cleansing formulations of the skin, mucosa and the auricle. Therefore a further aspect of the present invention are the said cleansing or sanitizing formulations for the skin, mucosa or ear comprising at least one of said agents with bacteriostatic, mycostatic, yeaststatic and/or microbicide activity.

A further aspect of the present invention is a process for preparing the salt of formula which comprises the following steps: esterifying dimethylaminoethanol with a halide of formula RCOX', wherein X' is a halogen selected from chloride or bromide, optionally in the presence of a hydrogen ion acceptor, thus obtaining the ester of formula, wherein R has the aforesaid meanings; salifying the ester of formula by treating the reaction mixture derived from the first step in order to obtain the salts of formula.

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