Bissett et al report that topical application of niacinamide reduces yellowing, wrinkling, red blotchiness and hyperpigmented spots in aging facial skin.1 Previous clinical testing of topical niacinamide (vitamin B3) has revealed a broad array of improvements in the appearance of aging facial skin. The study reported here was performed to confirm some of those previous observations and to evaluate additional end points such as skin antiyellowing. Caucasian female subjects (n = 50, aged 40-60 years) participated in a 12-week, double-blind, placebo-controlled, splitface, left-right, randomized clinical study that assessed 2 topical products: moisturizer control product vs. the same moisturizer product containing 5% niacinamide. Niacinamide was well tolerated by the skin and provided signifi cant improvements in comparison with the control in end points evaluated previously (i.e., fi ne lines/wrinkles, hyperpigmentation spots, texture and red blotchiness). In addition, skin yellowing (sallowness) compared with the control was signifi cantly improved. The mechanism by which this array of benefi ts is achieved with niacinamide is discussed.