According to a study published in the International Journal of Biological Macromolecules, collagen-keratin (CK) composites have drawn interest for the purpose of biomedical applications thanks to the biocompatibility and biodegradability of these two proteins.
Here, the authors explored the influence of keratin on collagen self-assembly, and the effects of varying concentrations of keratin nanoparticles (KNPs) on the fibrillogenesis of collagen. KNPs dose-dependently interacted with collagen I and appeared to influence the hydrogen bonding interaction in collagen molecules.
Furthermore, the introduction of KNPs did not interrupt collagen self-assembly. CK composites also showed a better cellular affinity compared with the collagen. As such, the authors propose these composites as candidates for biomedical applications.
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