Protecting the Skin from Environmental Stresses with an Exopolysaccharide Formulation

January 30, 2009 | Contact Author | By: A. Thibodeau, Atrium Biotechnologies
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Keywords: Polysaccharide | exopolysaccharides | hydrothermal | epidermis | ICAM-1 | leucocytes | keratinocytes | interferon | fibroblasts

Abstract: A polysaccharide with a repetitive unit of 11 glycosidic residues has been found to exert properties such as skin repair, restructuring and protection against inflammatory processes, in a described formulation.

An increasing number of hyperthermophilic and mesophilic bacteria have been isolated from deep-sea hydrothermal vents throughout the past 20 years and found to be an extraordinary source of innovative molecules with unusual biological properties. These properties have developed as defense mechanisms enabling the marine organisms to adapt themselves to extreme conditions of temperature, pressure and darkness that prevail in the world’s seas.


Among these, bacteria belonging to the genus Alteromonas, and precisely to the species A. macleodii, were identifi ed as being able to produce large amounts of biologically active exopolysaccharides (EPS). A close investigation of some of these biopolymers revealed that they could be of powerful value in the cosmetic industry by providing a new way to protect the skin from environmental injuries. The best example is a polysaccharide produced by A. macleodii, strain HYD657a (EPS657) that is the sole bioactive polymer in a described Alteromonas ferment extract formulationb (SEPS657). The present review will focus on this ferment extract with particular emphasis on its properties as exemplifi ed by a number of laboratory and clinical studies. A separate article on page 26 discusses the scheme of events that led to its discovery.