Targeting the Long Non-coding RNA “nc886” as a New Pathway to Skin Rejuvenation


For the first time, an active ingredient targets a long non-coding RNA to fight at the same time the three causes of aging: chronoaging, photoaging and inflammaging.

Ground-breaking research conducted by Clariant Active Ingredients has demonstrated that the level of expression of nc886 decreases with age after 40 years old and is directly linked to the alteration of skin structure. These research lead to the development of Epseama™, an active ingredient that boosts nc886 expression and consequently inhibits the production of MMP-9 to prevent collagen degradation. It also induces the production of collagen VII and XVII as well as laminin 5 to strengthen the junction between dermis and epidermis.

As a result, Epseama demonstrated outstanding performance in the treatment of difficult-to-remove nasolabial wrinkles, decreasing them by 19% in volume and 10% in roughness. It also decreased spots by 10% and increased skin moisture by 14.2%, for a rejuvenated look.

For more information please visit http://www.clariant.com/epseama.


The above paid-for content was produced by and posted on behalf of the Sponsor. Content provided is generated solely by the Sponsor or its affiliates, and it is the Sponsor’s responsi­bility for the accuracy, completeness and validity of all information included. Cosmetics & Toiletries takes steps to ensure that you will not confuse sponsored content with content produced by Cosmetics & Toiletries and governed by its editorial policy.

More in Anti-aging/Face